Table 3 Outcomes of nitroglycerin-cyclodextrins (CDs) inclusion complex (FAkito et al. 1978)
From: Chronicle updates in cyclodextrin-based carriers for drug delivery
Decomposition temperature | Nitroglycerin conventional formulation:very small Nitroglycerin-CD complex: 192 °C |
Evaporation rate | Nitroglycerin conventional formulation: 1 Nitroglycerin-CD complex: 1/10 |
Evaporation content after 10 days 50 °C | Nitroglycerin conventional formulation: 100% Other cellulose-based formulation: 81% Nitroglycerin-CD complex: 42% |
Sublingual delivery to healthy human | Nitroglycerin-CD complex: Heart rate and blood pressure significantly higher than placebo and slightly higher than conventional formulation |