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Table 2 Phase I (1975–1980) of cyclodextrin (CDs) development

From: Chronicle updates in cyclodextrin-based carriers for drug delivery

Year

CD type

Drug

Studies

Reference

1975

β

Phenothiazine

Inclusion formation and characterization

Otagiri et al. (1975)

1975

β

Fenamates

Inclusion formation and characterization

Ikeda et al. (1975)

1976

β

Barbiturates

Inclusion formation and characterization

Otagiri et al. (1976)

1978

β

Stability constants for barbiturates, phenothiazines sulfonylureas, etc.

Inclusion formation and characterization

Uekama et al. (1978a)

1978

β

Sulphonamide

Inclusion formation and characterization

Uekama et al. (1978b)

1978

β

Nitroglycerin

Inclusion formation and characterization, resolving volatility problem of nitroglycerin increasing bioavailability

FAkito et al. (1978)

1979

β

Acetohexamide

animal studies

Uekama et al. (1979a)

1979

β

Prostaglandins

dissolution and chemical stability studies

Uekama et al. (1979b)

1980

β

Indomethacin inclusion complexes

in vivo bioavailability studies, anti-inflammatory activity and ulcer toxicity studies

Szejtli et al. (1980)

1980

β

Barbiturates

animal studies

Koizumi et al. (1980a)

1980

α, β

Prostaglandins attachment changes molecular dynamic of CDs

Inclusion formation and characterization

Hirayama et al. (1980)

1980

β

Tolbutamide chlorpropamide

Inclusion formation and characterization

Ueda and Nagai (1980)