Neonatal orally administered curcumin: impact on the metabolic response and renal histology of Sprague-Dawley rats fed a high-fructose diet until adolescence

Bulletin of the National Research Centre

Table 6 High-fructose diet induced changes in renal histomorphometry (post-natal day 63) of male and female rats administered curcumin during suckling

Treatment groups	RCA (µm²)	GTA (µm²)	BCA (µm²)
Male rats
DMSO + TW	8497 ± 456^a	5170 ± 306^b	3327 ± 261^c
DMSO + FW	7745 ± 378^a	4385 ± 201^b	2910 ± 280^c
CC + TW	8515 ± 297^a	5419 ± 165^b	3096 ± 217^c
CC + FW	8782 ± 362^a	5349 ± 248^b	3433 ± 364^c
FW + TW	8329 ± 388^a	5459 ± 293^b	2870 ± 142^c
FW + FW	7718 ± 291^a	4529 ± 190^b	3189 ± 290^c
CCFW + TW	8881 ± 123^a	5452 ± 168^b	3429 ± 187^c
CCFW + FW	8381 ± 325^a	5119 ± 203^b	3261 ± 350^c
p values	0.144	0.141	0.689
Female rats
DMSO + TW	8346 ± 338^a	5251 ± 273^b	3185 ± 304^c
DMSO + FW	7835 ± 166^a	4784 ± 127^b	3051 ± 224^c
CC + TW	8609 ± 307^a	5215 ± 213^b	3395 ± 249^c
CC + FW	8673 ± 242^a	5239 ± 253^b	3434 ± 244^c
FW + TW	8364 ± 268^a	5115 ± 203^b	3249 ± 244^c
FW + FW	7698 ± 141^a	4502 ± 171^b	3196 ± 182^c
CCFW + TW	8692 ± 158^a	5001 ± 158^b	3691 ± 203^c
CCFW + FW	8578 ± 140^a	5147 ± 143^b	3430 ± 146^c
p values	0.101	0.114	0.591

^{a, b, c}Means across columns (in males and females) with similar superscripts are similar (p > 0.05) using one-way ANOVA across all eight groups for the RCA, GTA and BCA. RCA, renal corpuscular area; GTA, glomerular tuft area; BCA, bowman capsular area. DMSO + TW = 10 ml kg⁻¹ of a 0.5% dimethyl sulphoxide solution as neonates and plain tap water post-weaning, DMSO + FW = 10 ml kg⁻¹ of a 0.5% dimethyl sulphoxide solution as neonates and fructose (20%, w/v) as drinking fluid in the growing period, CC + TW = curcumin (500 mg kg⁻¹ in 0.5% DMSO) as neonates and plain tap water in the growing period, CC + FW = curcumin (500 mg kg⁻¹ in 0.5% DMSO) as neonates and fructose (20%, w/v) as drinking fluid in the growing period, FW + TW = fructose (20%, w/v) as neonates and plain tap water in the growing period, FW + FW = fructose (20%, w/v) as neonates and fructose (20%, w/v) as drinking fluid in the growing period, CCFW + TW = curcumin (500 mg kg⁻¹) and fructose (20%, w/v) in 0.5% DMSO as neonates and plain tap water in the growing period, CCFW + FW = curcumin (500 mg kg⁻¹) and fructose (20%, w/v) in 0.5% DMSO as neonates and fructose (20%, w/v) in the growing period. Data expressed as mean ± SEM, n = 20 renal corpuscles and glomeruli per group