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Table 5 The effect of a high-fructose diet on the kidneys and pancreas mass at post-natal day 63 in male and female rats administered curcumin during suckling

From: Neonatal orally administered curcumin: impact on the metabolic response and renal histology of Sprague-Dawley rats fed a high-fructose diet until adolescence

Treatment groups

Kidneys (g)

Kidneys (%BM)

Pancreas (g)

Pancreas (%BM)

Male rats

DMSO + TW

2.00 ± 0.08a

0.72 ± 0.01b

0.96 ± 0.08c

0.35 ± 0.04d

DMSO + FW

1.90 ± 0.06a

0.71 ± 0.02b

1.00 ± 0.06c

0.36 ± 0.02d

CC + TW

2.00 ± 0.08a

0.71 ± 0.02b

1.00 ± 0.05c

0.36 ± 0.02d

CC + FW

1.90 ± 0.08a

0.73 ± 0.01b

1.00 ± 0.05c

0.40 ± 0.03d

FW + TW

2.20 ± 0.07a

0.72 ± 0.02b

1.20 ± 0.13c

0.40 ± 0.04d

FW + FW

2.20 ± 0.14a

0.86 ± 0.11b

0.92 ± 0.08c

0.35 ± 0.02d

CCFW + TW

2.20 ± 0.10a

0.74 ± 0.01b

1.20 ± 0.08c

0.42 ± 0.02d

CCFW + FW

2.00 ± 0.10a

0.76 ± 0.02b

1.10 ± 0.12c

0.41 ± 0.03d

p values

0.323

0.176

0.123

0.447

Female rats

DMSO + TW

1.50 ± 0.05a

0.71 ± 0.01b

0.77 ± 0.03c

0.38 ± 0.02d

DMSO + FW

1.50 ± 0.03a

0.74 ± 0.02b

0.89 ± 0.05c

0.44 ± 0.03d

CC + TW

1.50 ± 0.03a

0.71 ± 0.02b

0.84 ± 0.04c

0.40 ± 0.02d

CC + FW

1.60 ± 0.03a

0.78 ± 0.01b

0.88 ± 0.04c

0.43 ± 0.02d

FW + TW

1.50 ± 0.03a

0.72 ± 0.01b

0.94 ± 0.09c

0.44 ± 0.03d

FW + FW

1.60 ± 0.03a

0.74 ± 0.02b

0.88 ± 0.04c

0.41 ± 0.02d

CCFW + TW

1.50 ± 0.05a

0.72 ± 0.01b

0.85 ± 0.03c

0.40 ± 0.01d

CCFW + FW

1.60 ± 0.05a

0.75 ± 0.01b

0.94 ± 0.08c

0.45 ± 0.03d

p values

0.109

0.057

0.363

0.338

  1. a, b, c, dMeans across columns (in males and females) with similar superscripts are similar (p > 0.05) using one-way ANOVA across all eight groups for the masses of the viscera. DMSO + TW = 10 ml kg−1 of a 0.5% dimethyl sulphoxide solution as neonates and plain tap water post-weaning, DMSO + FW = 10 ml kg−1 of a 0.5% dimethyl sulphoxide solution as neonates and fructose (20%, w/v) as drinking fluid in the growing period, CC + TW = curcumin (500 mg kg−1 in 0.5% DMSO) as neonates and plain tap water in the growing period, CC + FW = curcumin (500 mg kg−1 in 0.5% DMSO) as neonates and fructose (20%, w/v) as drinking fluid in the growing period, FW + TW = fructose (20%, w/v) as neonates and plain tap water in the growing period, FW + FW = fructose (20%, w/v) as neonates and fructose (20%, w/v) as drinking fluid in the growing period, CCFW + TW = curcumin (500 mg kg−1) and fructose (20%, w/v) in 0.5% DMSO as neonates and plain tap water in the growing period, CCFW + FW = curcumin (500 mg kg−1) and fructose (20%, w/v) in 0.5% DMSO as neonates and fructose (20%, w/v) in the growing period. Data expressed as mean ± SEM, n = 7–9 per group