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Table 1 Growth pattern comparison across experimental groups with high fructose and curcumin treatment of male and female Sprague-Dawley rats (from post-natal day 6 to 63)

From: Neonatal orally administered curcumin: impact on the metabolic response and renal histology of Sprague-Dawley rats fed a high-fructose diet until adolescence

Treatments

Induction mass (g)

Weaning mass (g)

Terminal mass (g)

p value

Male rats

DMSO + TW

13 ± 1.00a

45 ± 1.40b

276 ± 12.00c

 < 0.001

DMSO + FW

14 ± 0.48a

44 ± 1.10b

276 ± 05.20c

 < 0.001

CC + TW

13 ± 0.85a

42 ± 1.40b

287 ± 14.00c

 < 0.001

CC + FW

14 ± 0.56a

42 ± 1.40b

260 ± 13.00c

 < 0.001

FW + TW

15 ± 0.60a

45 ± 2.90b

303 ± 14.00c

 < 0.001

FW + FW

15 ± 0.46a

45 ± 1.80b

259 ± 11.00c

 < 0.001

CCFW + TW

13 ± 0.93a

46 ± 2.10b

295 ± 15.00c

 < 0.001

CCFW + FW

14 ± 0.46a

44 ± 2.20b

268 ± 18.00c

 < 0.001

Female rats

DMSO + TW

12 ± 0.45a

43 ± 1.10b

206 ± 07.10c

 < 0.001

DMSO + FW

14 ± 0.42a

41 ± 1.50b

203 ± 05.80c

 < 0.001

CC + TW

13 ± 0.50a

41 ± 1.50b

210 ± 03.70c

 < 0.001

CC + FW

14 ± 0.50a

42 ± 1.60b

207 ± 03.10c

 < 0.001

FW + TW

13 ± 0.20a

45 ± 2.00b

211 ± 05.90c

 < 0.001

FW + FW

13 ± 0.33a

42 ± 1.10b

215 ± 04.00c

 < 0.001

CCFW + TW

13 ± 0.63a

43 ± 1.90b

212 ± 06.90c

 < 0.001

CCFW + FW

13 ± 0.46a

39 ± 1.60b

210 ± 05.90c

 < 0.001

  1. Different superscripts a, b, c indicate significant difference (p < 0.0001) in mass across time points (i.e. across rows; induction, weaning and terminal), using ANOVA and Bonferroni post hoc test. Induction mass: post-natal day (PN) 6, weaning mass: PN 21, terminal mass: PN 63. DMSO + TW = 10 ml kg−1 of a 0.5% dimethyl sulphoxide solution as neonates and plain tap water post-weaning, DMSO + FW = 10 ml kg−1 of a 0.5% dimethyl sulphoxide solution as neonates and fructose (20%, w/v) as drinking fluid post-weaning, CC + TW = curcumin (500 mg kg−1 in 0.5% DMSO) as neonates and plain tap water post-weaning, CC + FW = curcumin (500 mg kg−1 in 0.5% DMSO) as neonates and fructose (20%, w/v) as drinking fluid post-weaning, FW + TW = fructose (20%, w/v) as neonates and plain tap water post-weaning, FW + FW = fructose (20%, w/v) as neonates and fructose (20%, w/v) as drinking fluid post-weaning, CCFW + TW = curcumin (500 mg kg−1) and fructose (20%, w/v) in 0.5% DMSO as neonates and plain tap water post-weaning, CCFW + FW = curcumin (500 mg kg−1) and fructose (20%, w/v) in 0.5% DMSO as neonates and fructose (20%, w/v) post-weaning. Data expressed as mean ± SEM, n = 7–9 per group