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Table 3 Effects of naloxone on RAF of ethanol leaf extract of Ipomoea asarifolia on PTZ-induced seizure in mice

From: Anticonvulsant activity and mechanism of actions of fractions of Ipomoea asarifolia (Desr) (Convolvulaceae) ethanol leaf extract

Treatment (mg/kg)

Onset of seizures (Min.)

Quantal protection

% Protection against seizures

% Protection against mortality

D/W (10 ml/kg)

4.00 ± 0.26

0/6

0.00

66.67

RAF (75)

10.17 ± 1.70*

1/6

16.67

83.33

NAL (1)

6.00 ± 1.14

0/6

0.00

50.00

NAL (1) + RAF (75)

5.80 ± 0.97#

1/6

16.67

100.00

SV (200)

6/6

100.00

100.00

NAL (1) + SV (200)

20.00 ± 5.13**

3/6

50.00

100.00

DZP (5)

6/6

100.00

100.00

NAL (1) + DZP (5)

6/6

100.00

100.00

  1. D/W, distilled water; RAFI, residual aqueous fraction of Ipomoea asarifolia; NAL, naloxone; DZP, diazepam; SV, sodium valproate
  2. Values are presented as mean ± SEM
  3. *P < 0.05; **P < 0.01 as compared to D/W group
  4. #P < 0.05 as compared to RAF group—One-way ANOVA followed by Tukey post hoc test, n = 6