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Table 2 The composition of Box–Behnken design points

From: Formulation and optimization of polymeric agglomerates of Bosentan monohydrate by crystallo-co-agglomeration technique

Formulation code

Talc (%)

PEG 6000 (%)

Speed (RPM)

BOS 1

2.00

3.50

1000

BOS 2

2.00

5.00

800

BOS 3

2.00

3.50

600

BOS 4

0.50

2.00

800

BOS 5

1.25

5.00

600

BOS 6

0.50

5.00

800

BOS 7

0.50

3.50

1000

BOS 8

0.50

3.50

600

BOS 9

1.25

2.00

600

BOS 10

2.00

2.00

800

BOS 11

1.25

2.00

1000

BOS 12

1.25

3.50

800

BOS 13

1.25

3.50

1000