Table 1 Experimental design detail for optimization of SAs
Independent factors | Coded value | Uncoded value | ||||
|---|---|---|---|---|---|---|
Low | Medium | High | Low | Medium | High | |
Concentration of talc (%) (A) | − 1 | 0 | 1 | 0.5 | 1.25 | 2.0 |
Concentration of PEG 6000(%) (B) | − 1 | 0 | 1 | 2.0 | 3.5 | 5.0 |
Rotation speed (RPM) (C) | − 1 | 0 | 1 | 600 | 800 | 1000 |
Dependent factors | ||||||
Y1 = Particle size (µ m) | ||||||
Y2 = Angle of repose (degree) | ||||||
Y3 = Drug content (%) | ||||||