Table 7 Effects of aspartame in various diseases
From: Is the consumption of energy drink beneficial or detrimental to health: a comprehensive review?
Type of disease | Influence of Aspartame |
|---|---|
Obesity | It is unclear if obesity is associated with the consumption or products containing aspartame |
Diabetes mellitus | The connection between aspartame and TD2 risk is unclear |
Impact on children and fetus | Aspartame may have influence on children and fetuses |
Genotoxicity | Aspartame may have genotoxic properties |
Behavioral disorders | Aspartame can cause long-term changes in behavior |
Autism | Aspartame itself does not trigger autism |
Neurodegeneration | Aspartame cause mental stress, affects learning skills and memory. Aspartame is also amyloidogenic |
Neurotransmission | Aspartame reduces catecholamine levels |
Hormones | Aspartame elevates plasma corticosterone level and plasma adrenocorticotropic level |
Allergies and skin problems | Aspartame can induce systemic contact dermatitis (in huge daily doses which lead to formaldehyde accumulation). 0.5 μg kg−1 and 0.5 mg μg kg−1 doses of aspartame reduces some atopic dermatitis symptoms |
Phenylketonuria | Aspartame intake rises plasma Phe level. People suffering from phenylketonuria should avoid products containing aspartame |
Cancer | Aspartame may have carcinogenic properties but further studies are needed |
Inflammation | Aspartame caused neurotoxicity, oxidative stress, and inflammation in rat brain tissue |
Preterm birth and maternity problem in women | aspartame increased risk of preterm birth, allergic reactions, weight growth in babies, early first menstruation, aspartame is linked to autism in children |
Reduction of antioxidant enzyme activity | Aspartame use lowers hepatic tissue SOD, CAT, activity in renal tissue, and GSH levels while increasing GST activity in liver tissue |