Table 4 Percentage and logarithmic reductions in bacterial cells exposed to fluoroquinolone antibiotics
Isolate codes | Exposed time (h) | OFL | LEV | CIP | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
PC (CFU/ml) | Log10 CFU/ml | %/Log reduction | PC (CFU/ml) | Log10 (CFU/ml) | %/Log reduction | PC (CFU/ml) | Log10 CFU/ml | %/Log reduction | ||
PA09 | 0 | 4.6 × 105 | 5.66 | NA/NA | 4.0 × 105 | 5.60 | NA/NA | 4.1 × 105 | 5.61 | NA/NA |
6 | 5.0 × 104 | 4.70 | 89.1/0.97 | 4.9 × 104 | 4.69 | 87.8/0.91 | 5.0 × 104 | 4.70 | 87.8/0.91 | |
12 | 2.5 × 103 | 3.40 | 95.0/1.3 | 1.3 × 103 | 3.11 | 97.3/1.58 | 3.2 × 103 | 3.51 | 93.6/1.39 | |
18 | 3.1 × 102 | 2.49 | 87.6/0.9 | 2.9 × 102 | 2.46 | 77.7/0.65 | 3.0 × 102 | 2.48 | 90.6/1.03 | |
24 | 1.4 × 102 | 2.15 | 54.8/0.35 | 1.5 × 102 | 2.18 | 48.3/0.29 | 1.2 × 102 | 2.08 | 60.0/0.4 | |
30 | NG | 0.0 |  ≥ 99.9/2.14 | 1.0 × 102 | 2.0 | 33.3/0.17 | NG | 0.0 |  ≥ 99.9/2.08 | |
0 | 5.1 × 105 | 5.71 | NA/NA | 4.5 × 105 | 5.65 | NA/NA | 4.0 × 105 | 5.60 | NA/NA | |
6 | 2.6 × 105 | 5.41 | 49.0/0.3 | 5.3 × 104 | 4.72 | 88.2/0.93 | 5.6 × 104 | 4.75 | 86/0.85 | |
HI27 | 12 | 6.0 × 104 | 4.78 | 76.9/0.63 | 3.1 × 104 | 4.49 | 41.5/0.23 | 4.1 × 103 | 3.61 | 92.7/1.14 |
18 | 4.3 × 103 | 3.63 | 92.8/1.15 | 2.0 × 103 | 3.30 | 93.5/1.19 | 2.9 × 102 | 2.46 | 92.9/1.15 | |
24 | 2.1 × 102 | 2.32 | 95.1/1.31 | 1.0 × 102 | 2.0 | 95.0/1.3 | 1.0 × 102 | 2.0 | 65.5/0.46 | |
30 | 1.0 × 102 | 2.0 | 52.4/0.32 | NG | 0.0 |  ≥ 99.9/2.0 | NG | 0.0 |  ≥ 99.9/2.0 | |
AS01 | 0 | 3.9 × 105 | 5.59 | NA/NA | 3.6 × 105 | 5.56 | NA/NA | 3.0 × 105 | 5.48 | NA/NA |
6 | 2.8 × 104 | 4.45 | 92.8/1.14 | 2.0 × 104 | 4.30 | 94.4/1.26 | 4.1 × 104 | 4.61 | 86.3/0.87 | |
12 | 1.6 × 103 | 3.20 | 94.3/1.25 | 3.4 × 103 | 3.53 | 83.0/0.77 | 2.6 × 103 | 3.41 | 93.7/1.2 | |
18 | 1.1 × 102 | 2.04 | 93.1/1.16 | 1.5 × 102 | 2.18 | 95.6/1.35 | 2.0 × 102 | 2.30 | 92.3/1.11 | |
24 | 1.0 × 102 | 2.0 | 90.9/0.04 | 1.2 × 102 | 2.08 | 20/0.1 | 1.7 × 102 | 2.23 | 15/0.07 | |
30 | NG | 0.0 |  ≥ 99.9/2.0 | 1.0 × 102 | 2.0 | 16.7/0.08 | NG | 0.0 |  ≥ 99.9/2.23 | |
KP32 | 0 | 6.9 × 105 | 5.84 | NA/NA | 5.4 × 105 | 5.73 | NA/NA | 5.4 × 105 | 5.73 | NA/NA |
6 | 1.1 × 105 | 5.04 | 84.1/1.26 | 6.0 × 104 | 4.78 | 88.9/0.95 | 4.8 × 104 | 4.68 | 91.1/1.05 | |
12 | 1.0 × 104 | 4.0 | 90.9/0.77 | 3.5 × 103 | 3.54 | 94.2/1.24 | 2.5 × 103 | 3.40 | 94.8/1.28 | |
18 | 3.6 × 103 | 3.56 | 64.0/1.35 | 5.1 × 102 | 2.71 | 85.4/0.83 | 1.2 × 102 | 2.08 | 95.2/1.32 | |
24 | 1.7 × 102 | 2.23 | 95.3/0.1 | 1.1 × 102 | 2.04 | 78.4/0.67 | NG | 0.0 |  ≥ 99.9/2.08 | |
30 | 1.0 × 102 | 2.0 | 41.2/0.08 | NG | 0.0 |  ≥ 99.9/2.04 | NG | 0.0 |  ≥ 99.9/0.0 | |
ST07 | 0 | 3.3 × 105 | 5.52 | NA/NA | 3.7 × 105 | 5.57 | NA/NA | 3.1 × 105 | 5.49 | NA/NA |
6 | 4.7 × 104 | 4.67 | 85.8/0.85 | 2.9 × 104 | 4.46 | 92.2/1.11 | 4.2 × 104 | 4.62 | 86.5/0.87 | |
12 | 1.5 × 103 | 3.18 | 96.8/1.49 | 2.5 × 103 | 3.40 | 91.4/1.06 | 1.5 × 103 | 3.18 | 96.4/1.44 | |
18 | 2.5 × 102 | 2.40 | 83.3/0.78 | 1.9 × 102 | 2.28 | 92.4/1.12 | 2.9 × 102 | 2.46 | 80.7/0.72 | |
24 | 2.1 × 102 | 2.32 | 16.0/0.08 | 1.0 × 102 | 2.0 | 47.4/0.28 | 2.4 × 102 | 2.38 | 17.2/0.08 | |
30 | 1.0 × 102 | 2.0 | 52.4/0.32 | NG | 0.0 |  ≥ 99.9/2.0 | 1.5 × 102 | 2.18 | 37.5/0.2 | |
EA01 | 0 | 4.5 × 105 | 5.65 | NA/NA | 5.7 × 105 | 5.76 | NA/NA | 4.0 × 105 | 5.60 | NA/NA |
6 | 3.4 × 104 | 4.53 | 92.4/1.13 | 2.6 × 104 | 4.41 | 95.4/1.35 | 2.9 × 105 | 5.46 | 27.5/0.14 | |
12 | 2.6 × 103 | 3.41 | 92.1/1.12 | 3.6 × 103 | 3.56 | 86.2/0.85 | 4.5 × 104 | 4.65 | 84.5/0.81 | |
18 | 2.0 × 103 | 3.30 | 23.1/0.11 | 2.4 × 102 | 2.38 | 93.3/1.18 | 3.1 × 103 | 3.49 | 93.1/1.16 | |
24 | 1.7 × 102 | 2.23 | 91.5/1.07 | 2.0 × 102 | 2.30 | 16.7/0.08 | 2.0 × 102 | 2.30 | 93.5/1.19 | |
30 | NG | 0.0 |  ≥ 99.9/2.23 | 1.1 × 102 | 2.04 | 45.0/0.26 | 1.4 × 102 | 2.15 | 30.0/0.15 | |
SA21 | 0 | 3.7 × 105 | 5.57 | NA/NA | 5.0 × 105 | 5.70 | NA/NA | 4.6 × 105 | 5.66 | NA/NA |
6 | 4.0 × 104 | 4.60 | 89.2/0.97 | 3.9 × 104 | 4.59 | 92.2/1.11 | 4.0 × 104 | 4.60 | 91.3/1.06 | |
12 | 2.1 × 103 | 3.32 | 94.8/1.28 | 2.0 × 103 | 3.30 | 94.9/1.29 | 2.5 × 104 | 4.40 | 37.5/0.20 | |
18 | 2.5 × 102 | 2.40 | 88.1/0.92 | 1.7 × 102 | 2.23 | 91.5/1.07 | 3.9 × 103 | 3.59 | 84.4/0.81 | |
24 | 2.0 × 102 | 2.30 | 20.0/0.1 | NG | 0.0 |  ≥ 99.9/2.23 | 2.6 × 102 | 2.41 | 93.3/1.18 | |
30 | 1.6 × 102 | 2.20 | 20.0/0.1 | NG | 0.0 |  ≥ 99.9/0.0 | 1.5 × 102 | 2.18 | 42.3/0.23 | |
SP02 | 0 | 4.1 × 105 | 5.61 | NA/NA | 3.8 × 105 | 5.58 | NA/NA | 4.0 × 105 | 5.60 | NA/NA |
6 | 1.0 × 105 | 5.00 | 75.6/0.61 | 6.5 × 104 | 4.81 | 82.9/0.77 | 1.0 × 105 | 5.00 | 75.0/0.6 | |
12 | 6.3 × 104 | 4.80 | 37.0/0.20 | 4.1 × 103 | 3.61 | 93.7/1.20 | 5.5 × 104 | 4.74 | 45.0/0.26 | |
18 | 3.5 × 103 | 3.54 | 94.4/1.26 | 2.7 × 102 | 2.43 | 93.4/1.18 | 3.4 × 103 | 3.53 | 93.8/1.21 | |
24 | 2.0 × 102 | 2.30 | 94.3/1.24 | 1.5 × 102 | 2.18 | 44.4/0.25 | 2.5 × 102 | 2.40 | 92.6/1.13 | |
30 | 1.3 × 102 | 2.11 | 35.0/0.19 | NG | 0.0 |  ≥ 99.9/2.18 | 1.0 × 102 | 2.00 | 60.0/0.40 | |