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Table 9 Assessment of kidney parameters in alloxan-induced diabetic rats after 21 days treatment of EMZSB

From: Screening of Manilkara zapota (L) P. Royen stem bark ethanolic extract for in vitro α-glucosidase inhibition, preliminary antidiabetic effects, and improvement of diabetes and its complications in alloxan-induced diabetes in Wistar rats

Groups Serum creatinine (mg dl−1) Serum albumin (g dl−1) Serum total protein (g dl−1)
Normal control 0.90 ± 0.67 5.67 ± 0.82 6.56 ± 0.38
Diabetic control 4.31 ± 0.42$ 2.36 ± 0.42$ 2.68 ± 0.68#
Diabetic + Glimepiride 1.00 ± 0.24* 5.60 ± 0.64* 5.93 ± 0.82*
Diabetic + EMZSB 150 3.58 ± 0.46 2.87 ± 0.28 3.14 ± 0.68
Diabetic + EMZSB 200 2.11 ± 0.67 4.68 ± 0.63 4.57 ± 0.92
Diabetic + EMZSB 250 1.20 ± 0.75* 5.48 ± 0.75* 5.85 ± 0.37*
  1. Values were presented as mean ± SEM. (n = 6); statistics employed was two-way ANOVA followed by Tukey's multiple comparison test. $p < 0.05, #p < 0.01 when compared with normal control; *p < 0.05 when compared with diabetic control