Screening of Manilkara zapota (L) P. Royen stem bark ethanolic extract for in vitro α-glucosidase inhibition, preliminary antidiabetic effects, and improvement of diabetes and its complications in alloxan-induced diabetes in Wistar rats

Bulletin of the National Research Centre

Table 8 Serum lipid profile in alloxan-induced diabetic rats when treated with EMZSB for 21 days

Groups	Serum HDL (mg dL⁻¹)	Serum LDL (mg dL⁻¹)	Serum cholesterol (mg dL⁻¹)	Serum triglyceride (mg dL⁻¹)
Normal control	78.18 ± 4.08	49.66 ± 2.09	88.56 ± 4.28	111.73 ± 8.27
Diabetic control	46.77 ± 3.48^$	77.75 ± 3.69^$	170.92 ± 6.38^#	165.92 ± 7.67^#
Diabetic + Glimepiride	75.94 ± 1.82^**	50.07 ± 1.18^**	141.64 ± 6.91^**	130.23 ± 6.84^***
Diabetic + EMZSB 150	68.59 ± 1.88	60.54 ± 2.47	176.14 ± 4.28	163.49 ± 7.51
Diabetic + EMZSB 200	69.98 ± 1.46	55.32 ± 3.59	152.38 ± 3.05	144.27 ± 3.34
Diabetic + EMZSB 250	71.63 ± 2.84^*	53.24 ± 2.08^*	146.67 ± 4.29^*	140.68 ± 5.46^*

Values were presented as mean ± SEM (n = 6); statistics employed was two-way ANOVA followed by Tukey's multiple comparison test. $p < 0.01, and #p < 0.001 when compared with normal control; *p < 0.05, **p < 0.01, and ***p < 0.001 when compared with diabetic control