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Table 7 Body weights changes in alloxan-induced diabetic rats when treated with EMZSB during 21 days treatment

From: Screening of Manilkara zapota (L) P. Royen stem bark ethanolic extract for in vitro α-glucosidase inhibition, preliminary antidiabetic effects, and improvement of diabetes and its complications in alloxan-induced diabetes in Wistar rats

Groups

Body weight changes (g)

7th day

14th day

21st day

Normal control

04.58 ± 2.15

6.47 ± 1.58

5.28 ± 2.78

Diabetic control

− 11.98 ± 4.84$

− 11.28 ± 3.64$

− 12.72 ± 4.38$

Diabetic + Glimepiride

2.28 ± 2.05

5.58 ± 2.68*

7.95 ± 2.45**

Diabetic + EMZSB 150

− 6.67 ± 2.08

− 4.72 ± 3.68

− 4.23 ± 1.61

Diabetic + EMZSB 200

− 5.88 ± 2.29

− 1.73 ± 2.86

3.55 ± 4.77*

Diabetic + EMZSB 250

− 2.54 ± 1.19

5.27 ± 3.89*

6.93 ± 4.83**

  1. Values were presented as mean ± SEM (n = 6), statistics employed was two-way ANOVA followed by Tukey's multiple comparison test. $p < 0.05 when compared with normal control; *p < 0.05, **p < 0.01 when compared with diabetic control. Diabetic rats treated with EMZSB 250 mg kg−1 showed a significant bodyweight gain at the end of study