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Table 5 Evaluation of oral glucose tolerance test in glucose-loaded rats when treated with EMZSB extract

From: Screening of Manilkara zapota (L) P. Royen stem bark ethanolic extract for in vitro α-glucosidase inhibition, preliminary antidiabetic effects, and improvement of diabetes and its complications in alloxan-induced diabetes in Wistar rats

Groups Blood glucose (mg dl−1) at
0th min 30th min 90th min 150th min
Normal control 76.25 ± 2.27 149.43 ± 3.47 141.68 ± 5.85 138.24 ± 2.62
Glimepiride 78.82 ± 3.56 128.62 ± 3.64* 117.11 ± 3.26** 96.04 ± 3.06***
EMZSB-150 76.36 ± 3.14 149.58 ± 3.45 139.57 ± 2.53 126.72 ± 5.42
EMZSB-200 77.21 ± 2.22 143.53 ± 5.18 136.57 ± 3.48 122.98 ± 5.61
EMZSB-250 78.47 ± 3.91 139.57 ± 3.47 130.42 ± 5.58 115.68 ± 4.05*
  1. Values were presented as mean ± SEM (n = 6), two-way ANOVA followed by Tukey’s test. A significant antihyperglycemic effect was elucidated by rats treated with EMZSB 250 mg kg−1
  2. When compared with normal control; *p < 0.05, **p < 0.01, and ***p < 0.001