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Bulletin of the National Research Centre

Table 5 Evaluation of oral glucose tolerance test in glucose-loaded rats when treated with EMZSB extract

From: Screening of Manilkara zapota (L) P. Royen stem bark ethanolic extract for in vitro α-glucosidase inhibition, preliminary antidiabetic effects, and improvement of diabetes and its complications in alloxan-induced diabetes in Wistar rats

Groups

Blood glucose (mg dl−1) at

0th min

30th min

90th min

150th min

Normal control

76.25 ± 2.27

149.43 ± 3.47

141.68 ± 5.85

138.24 ± 2.62

Glimepiride

78.82 ± 3.56

128.62 ± 3.64*

117.11 ± 3.26**

96.04 ± 3.06***

EMZSB-150

76.36 ± 3.14

149.58 ± 3.45

139.57 ± 2.53

126.72 ± 5.42

EMZSB-200

77.21 ± 2.22

143.53 ± 5.18

136.57 ± 3.48

122.98 ± 5.61

EMZSB-250

78.47 ± 3.91

139.57 ± 3.47

130.42 ± 5.58

115.68 ± 4.05*

  1. Values were presented as mean ± SEM (n = 6), two-way ANOVA followed by Tukey’s test. A significant antihyperglycemic effect was elucidated by rats treated with EMZSB 250 mg kg−1
  2. When compared with normal control; *p < 0.05, **p < 0.01, and ***p < 0.001
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