Screening of Manilkara zapota (L) P. Royen stem bark ethanolic extract for in vitro α-glucosidase inhibition, preliminary antidiabetic effects, and improvement of diabetes and its complications in alloxan-induced diabetes in Wistar rats

Bulletin of the National Research Centre

Table 3 α-glucosidase enzyme inhibition (%) by MZSB extracts

Concentration (µg/mL)	Acarbose		EMZSB		AEMZSB
Concentration (µg/mL)	% Inhibition	IC₅₀	% Inhibition	IC₅₀	% Inhibition	IC₅₀
25	9.82 ± 0.82	86.43 ± 1.26 µg mL⁻¹	6.14 ± 0.79	119.79 ± 1.52 µg mL⁻¹	4.43 ± 0.12	129.92 ± 2.29 µg mL⁻¹
50	22.76 ± 1.12		14.53 ± 0.93		12.94 ± 0.28
75	42.68 ± 0.92		28.41 ± 0.87		25.72 ± 0.76
100	57.48 ± 1.23		39.43 ± 0.88		33.95 ± 1.18
125	78.83 ± 1.67		52.61 ± 0.9		48.59 ± 0.92
150	95.24 ± 1.35		63.58 ± 1.05		59.67 ± 0.85