Table 2 Association of the ten studied polymorphisms with Schizophrenia assuming different genetic models
Polymorphism | Model | Genotype | Case, n (%) | Control, n (%) | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|
NRG1 /rs369770942 | – | AA | 102 (100) | 98 (100) | – | – |
miR-125a-3P/rs143525573 | – | GG | 102 (100) | 98 (100) | – | – |
3′UTR DRD2 rs200982455 | – | CC TT | 101 (99) 1 (0.01) | 95 (97) 3 (0.03) | 1 3.19 (0.33–31.20) | 0.28 |
MIR326 rs530404895 | – | CC | 102 (100) | 98 (100) | – | – |
MIR326 rs753764536 | – | GG | 102 (100) | 98 (100) | – | – |
MIR326 rs374732351 | – | GG | 102 (100) | 98 (100) | – | – |
3′UTR COMT rs4680 | – | AA | 102 (100) | 98 (100) | – | – |
3′UTR COMT rs165599 | Codominant | AA AG GG | 47 (46.1%) 45 (44.1%) 10 (9.8%) | 28 (28.6%) 63 (64.3%) 7 (7.1%) | 1.00 2.35 (1.28–4.30) 1.17 (0.40–3.44) | 0.016 |
dominant | AA AG/ GG | 47 (46.1%) 55 (53.9%) | 28 (28.6%) 70 (71.4%) | 1.00 2.14 (1.19–3.84) | 0.01 | |
Recessive | AA/AG GG | 92 (90.2%) 10 (9.8%) | 91 (92.9%) 7 (7.1%) | 1.00 0.71 (0.26–1.94) | 0.5 | |
Overdominant | AA/GG AG | 57 (55.9%) 45 (44.1%) | 35 (35.7%) 63 (64.3%) | 1.00 2.28 (1.29–4.03) | 0.004 | |
MIR124 rs340597269 | – | TT | 102 (100) | 98 (100) | – | – |
3′UTR RGS4 rs10759 | – | CC AA | 82 (80.4%) 20 (19.6%) | 78 (79.6%) 20 (20.4%) | 1.00 1.05 (0.53–2.10) | 0.89 |