Anti-inflammatory and analgesic activities of black cumin (BC, Nigella sativa L.) extracts in in vivo model systems

Bulletin of the National Research Centre

Table 1 Effects Black Cumin extracts by DMSO extracts of BC on carrageenan-induced paw in rats

Group	Dose (mg/kg, p.o.)	Paw edema volume (ml) (% of inhibition)
Group	Dose (mg/kg, p.o.)	1 h	2 h	3 h	4 h
Control	–	0.83 ± 0.02	0.96 ± 0.02	1.07 ± 0.02	1.18 ± 0.03
Diclofenac sodium	50	0.44 ± 0.0*	0.53 ± 0.02*	0.60 ± 0.01*	0.66 ± 0.01*
	50	47.18	45.32	44.10	43.79
	200	0.71 ± 0.01*	0.78 ± 0.01*	0.89 ± 0.02*	0.94 ± 0.03*
	200	14.15	19.03	16.26	20.62
Nigella sativa	400	0.63 ± 0.001*	0.74 ± 0.01*	0.83 ± 0.001*	0.85 ± 0.001*
	400	23.39	23.52	21.88	27.69
	800	0.61 ± 0.01*	0.70 ± 0.01*	0.81 ± 0.01*	0.83 ± 0.01*
	800	26.21	26.99	24.06	29.66