Skip to main content
Bulletin of the National Research Centre
Fig. 2 | Bulletin of the National Research Centre

Fig. 2

From: Anti-inflammatory and analgesic activities of black cumin (BC, Nigella sativa L.) extracts in in vivo model systems

Fig. 2

Possible mechanism of action of BC extracts to reduce inflammation in humans. In the BC extracts, phenols and polyphenols, e.g., ferulic acid, p-coumaric acid, kaempferol, and quercetin, inhibit the signaling molecules, stimulation of which may directly or indirectly result in inflammation. Proteins linked to inflammation participate in several canonical pathways underlying a range of biological activities. Ingenuity pathway analysis (IPA) identified that the BC extracts' components could target many of these proteins (Additional file 1: Table S1) and control inflammation. Arrows (↓) indicate direct stimulatory modification, whereas light-up signs (┬) indicate an inhibitory modification. The names of the proteins followed the Hugo nomenclature, NCBI Entrez, UniProtKB/Swiss-Prot system

Back to article page