Table 10 Comparison of docking results between currently prescribed drugs and selected bioactive compounds against three target proteins
| Â | Compounds | Binding affinity (kcal/mol) with CotH3 | Binding affinity (kcal/mol) with Lanosterol 14 alpha-demethylase | Binding affinity (kcal/mol) with mucoricin |
|---|---|---|---|---|
Selected candidates | 12,28-Oxamanzamine A |  − 10.2 |  − 10.9 |  − 8.6 |
Vialinin B |  − 8.9 |  − 7.8 |  − 6.5 | |
Deoxytopsentin |  − 8.5 |  − 9.5 |  − 7.2 | |
Pramiconazole |  − 7.6 |  − 11 |  − 7.1 | |
Saperconazole |  − 7.8 |  − 10.8 |  − 7 | |
Hesperidin |  − 8 |  − 10 |  − 8 | |
Currently prescribed drugs for mucormycosis | Posaconazole |  − 7.8 |  − 9.8 |  − 6.4 |
Isavuconazole |  − 6.5 |  − 9.2 |  − 5.9 |