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Table 4 Kidney parameters of rats following 28-day repeated administration of Culcasia angolensis leaves extract (CAE)

From: Preliminary sub-acute toxicological assessment of methanol leaves extract of Culcasia angolensis (Araceae) in Wistar rats

Parameters Treatment group (mg/kg)
DW (1 ml/kg) CAE (125) CAE (250) CAE (500)
Urea (mmol/L) 32.2 ± 1.22 30.80 ± 0.89 31.66 ± 2.70 38.40 ± 1.82*
Creatinine (mmol/L) 0.80 ± 0.05 0.85 ± 0.11 0.88 ± 0.12 0.90 ± 0.60
Sodium (mmol/L) 220.32 ± 7.44 221.56 ± 2.99 225.08 ± 6.91 222.98 ± 3.24
Potassium (mmol/L) 7.90 ± 0.10 6.76 ± 1.20 7.30 ± 0.36 6.60 ± 2.27
Chloride (mmol/L) 96.67 ± 5.39 98.67 ± 5.26 87.83 ± 3.02 89.40 ± 1.50
Bicarbonate (mmol/L) 88.8 ± 3.30 88.60 ± 2.11 94.50 ± 3.71 89.84 ± 1.82
  1. The values were tabulated as mean ± SEM; *p ≤ 0.05 compared to control group (one-way ANOVA followed by Dunnett's post hoc test), n = 6
  2. DW distilled water, CAE Culcasia angolensis leaves extract