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Fig. 11 | Bulletin of the National Research Centre

Fig. 11

From: Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo

Fig. 11

Effect of each of l-dopa and rasagiline (R) alone or in combination with caffeine (CAF) or coffee (COF) on GFAP immunohistochemically stained brain tissue sections in paraquat (PQ)-treated mice. A Normal mice showing normal small GFAP+ve astrocytes (arrows), with surrounding normal neurons. B PQ-treated mice showing astrogliosis with numerous large deeply stained GFAP+ve astrocytes with numerous branching processes (arrows). C l-dopa + CAF + PQ-treated mice showing marked reduction of GFAP+ve astrocytes (arrow). DF Mice treated with l-dopa + COF + PQ, l-dopa + PQ and R + CAF + PQ showing reduction in GFAP+ve astrocytes (arrows). G, H R + COF + PQ and R + PQ-treated mice showing several GFAP+ve astrocytes (arrows) (IHC ×400)

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