Endophytic microbes from Nigerian ethnomedicinal plants: a potential source for bioactive secondary metabolites—a review

Ezeobiora, Chijioke E.; Igbokwe, Nwamaka H.; Amin, Dina H.; Mendie, Udoma E.

doi:10.1186/s42269-021-00561-7

Bulletin of the National Research Centre

Table 1 Reports of isolated endophytes from Nigerian plants

From: Endophytic microbes from Nigerian ethnomedicinal plants: a potential source for bioactive secondary metabolites—a review

Compounds	Plant name	Plant part	Endophyte	Growth media	Method of urification	Activity	References
Acropyrone, Indole-3-acetic acid	Chromolaena. odorata	Leaves	Endophytic fungi	PDA	HPLC	Antimicrobial, Antioxidant	Buzugbe et al. (2018)
Glucobrassin, Ferulic acid, 4-Methoxybenzaldehyde, 12 Hydroxy-16-scaleren, 12-o-Deacetyl-12-episcalarin, Ixoside, Citreodrimene F, Cytosporin D	Azadirachta indica	Leaves, Stem	Aureobasidium sp., Sodaria sp., Aspergillus sp., Penicillium sp.	Rice medium, MEA	HPLC–DAD	Antimicrobial	Ujam et al. (2011)
Citreoisocoumarin, Citreoisocoumarinol, Questinol, Hydroxyemodin, Acropyrone, Nigricinol, Cladosporin	Catharanthus roseus	Leaves, Stem	Endophytic fungi	Rice medium, PDA	HPLC–DAD analysis	Antimicrobial	Akpotu et al. (2020)
Protocathechuic acid, Indole-3-acetic acid, Acropyrone	Citrus jambhiri	Leaves	Endophytic fungi	Rice media, PDA	HPLC analysis	Antibacterial	Eze et al. (2018)
Citreoisocoumarinol, Acropyrone, Citreoisocoumarin	Psidium guajava	Leaves	Nectria sp., Microdochium bolleyi, Fusarium tricinctum, Penicillum sp.	MEA, Rice medium	HPLC analysis	Antioxidant, Anticancer	(2018)
Indole-3-acetic acid, Indole-3-carbeldehyde	Carica papaya	Leaves	Endophytic fungi	Rice medium, MEA	HPLC analysis	Antimicrobial	Abba and Nduka (2016)
Ethyl-4-hydroxyphenyl acetate, Ferulic acid, Ruspolinone	Newbouldia laevis	Leaves	Endophytic fungi	Rice medium, MEA	HPLC analysis	Antibacterial	Okezie et al. (2017)
Acropyrone	Loranthus micranthus	Leaves	Aspergillus sp.	PDA	HPLC analysis	Antibacterial, Antioxidant	Akpotu et al. (2017)
Protocatechuic acid, Cladosporin, Scytalone	Ocimum gratissimum	Leaves	Endophytic fungi	MEA	HPLC	Antimicrobial	Abba et al. (2018)
4-Hydroxy phenyl acetic acid, p-Methoxycoumaric acid, Indole-3-acetic acid, Acropyrone	Vernonia amygdalina	Leaves	Endophytic fungi	MEA	HPLC–DAD analysis	Antimicrobial	Abba et al. (2018)
Citreoisocumarinol, Cladosporin, Acropyrone	Euphorbia hirta	Leaves	Endophytic fungi	Rice medium, MEA	HPLC–DAD	Antimicrobial, Antioxidant	Abonyi and Eze (2018)
Phenolic compounds	Annona muricata	Leaves	Pseudofusicoccum sp.	Rice medium	HPLC	Antimicrobial	Nwachukwu et al. (2018)
p-Hydroxyphenyl acetic acid, Ferulic acid	Moringa oleifera	Leaves	Endophytic fungi	PDA, Rice media	HPLC analysis	Antimicrobial, Antioxidant, Anticancer	Garba et al. (2018)
Acropyrone, 4-Hydroxy phenylacetic acid, Indole-3-acetic acid	Picralima nitida	Leaves	Curvularia sp.	PDA, rice medium	HPLC	Antimicrobial	Morare et al. (2018)
Fatty acid ester, 6-(5-Ethoxypentyl-2-methylhex-2-enedioate	Sclerocarya birreas	Stem, Bark	Fusarium oxysporum	PDA	Silica gel column chromatography	Antimicrobial	Ujam et al. (2020)

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