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Table 2 Significant genes involved in COVID-19

From: Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity

S. no. Genes Chromosome location Total exons Function Clinical significance References
1. Angiotensin-converting enzyme-2 (ACE-2) Xp22.2 20 Functional receptor for the spike glycoprotein of HCV-NL63, SARS, and SARS-CoV-2 It is a causative (COVID-19). It is under review for the study of coronavirus biology and its involvement of ACE-2 with SARS-CoV-2 www.ncbi.nlm.nih.gov
2. (a) Interleukin-2 (IL-2) 4q27 4 Cytokine produced by activated CD4 + and CD8 + T lymphocytes that is important for the proliferation of T and B lymphocytes IL-2 is under review for the study of coronavirus biology, and it is involved in cytokine storm inflammatory response www.ncbi.nlm.nih.gov
(b) Interleukin-7 (IL-7) 8q21.13 8 In association with the disease severity of COVID-19, circulating cytokines and chemokines have been found IL-7 is under review for the study of coronavirus biology, and it is involved in cytokine storm inflammatory response www.ncbi.nlm.nih.gov
(c) Interleukin-10 (IL-10) 1q32.1 7 This cytokine can block NF-kappa B activity, and it is involved in the regulation of the JAK-STAT signaling pathway IL-10 is under review for the study of coronavirus biology, and it is involved in cytokine storm inflammatory response www.ncbi.nlm.nih.gov
3. Tumor necrosis factor (TNF) 6p21.33 4 This cytokine regulates a broad spectrum of biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation TNF is under review for the study of coronavirus biology, and it is involved in cytokine storm inflammatory response www.ncbi.nlm.nih.gov
4. Vascular endothelial growth factor (VEGF) 6p21.1 9 This growth factor induces proliferation and migration of vascular endothelial cells and is essential for both physiological and pathological angiogenesis VEGF levels are higher during SARS-CoV-2 infection. This gene is under review for the study of coronavirus biology, and it is involved in cytokine storm inflammatory response www.ncbi.nlm.nih.gov