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Table 3 Mean percentage parasitaemia of mice treated with combined therapy

From: Antagonistic effects of some commonly used herbs on the efficacy of Artemisinin derivatives in the treatment of malaria in experimental mice

Treatment Grps Day1 Day2 Day3 Day4 Day5 Day6
Artesunate + Va 29.18 ± 0.13e 29.01 ± 0.13e 26.9 ± 0.17e 11.35 ± 0.07e 5.35 ± 0.7d 4.19 ± 0.07d
Artesunate + Mm 25.91 ± 0.13c 26.03 ± 0.13d 17.33 ± 0.13d 9.36 ± 0.07d 3.81 ± 0.07b 3.59 ± 0.07c
Artesunate + Ml 23.13 ± 0.13a 23.53 ± 0.13c 13.78 ± 0.13c 8.03 ± 0.07c 4.44 ± 0.07c 3.37 ± 0.07b
Artesunate 26.38 ± 0.13d 20.76 ± 0.13b 10.05 ± 0.13b 3.26 ± 0.07b 0.00 ± 0.00a 0.00 ± 0.00a
Chloroquine 25.75 ± 0.13b 17.48 ± 0.13a 8.56 ± 0.13a 2.5 ± 0.07a 0.00 ± 0.00a 0.00 ± 0.00a
Untreated 29.88 ± 0.13f 30.43 ± 0.13f 30.71 ± 0.13f 31.14 ± 0.00f 33.05 ± 0.00e 32.67 ± 0.03e
  1. Values were expressed as mean ± standard deviation (SD). Values with different superscripts (Alphabets) in a column are significantly different (p < 0.05) from each other. This implies that for each day, values with superscript (a) are the least value, followed by b then c, d e to f (highest). For example, at day 1, the lowest values for percentage parasitaemia were recorded in mice treated with artesunate + Ml followed by that of chloroquine while the highest parasitaemia was in untreated mice. These differences are statistically significant (all the values did not have similar superscript). At days 5 and 6, mice treated with artesunate and chloroquine have the least values for parasitaemia and both the same superscripts (a). This means they are not significantly different from one another. The opposite goes for mice treated with (artesunate + Mm) and (artesunate + Ml) at day 6. The former was significantly higher than the latter (p < 0.05) due to the fact that the two values share different superscripts (b and c)
  2. Mean values were from five mice observed in each group