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Table 3 Mean percentage parasitaemia of mice treated with combined therapy

From: Antagonistic effects of some commonly used herbs on the efficacy of Artemisinin derivatives in the treatment of malaria in experimental mice

Treatment Grps

Day1

Day2

Day3

Day4

Day5

Day6

Artesunate + Va

29.18 ± 0.13e

29.01 ± 0.13e

26.9 ± 0.17e

11.35 ± 0.07e

5.35 ± 0.7d

4.19 ± 0.07d

Artesunate + Mm

25.91 ± 0.13c

26.03 ± 0.13d

17.33 ± 0.13d

9.36 ± 0.07d

3.81 ± 0.07b

3.59 ± 0.07c

Artesunate + Ml

23.13 ± 0.13a

23.53 ± 0.13c

13.78 ± 0.13c

8.03 ± 0.07c

4.44 ± 0.07c

3.37 ± 0.07b

Artesunate

26.38 ± 0.13d

20.76 ± 0.13b

10.05 ± 0.13b

3.26 ± 0.07b

0.00 ± 0.00a

0.00 ± 0.00a

Chloroquine

25.75 ± 0.13b

17.48 ± 0.13a

8.56 ± 0.13a

2.5 ± 0.07a

0.00 ± 0.00a

0.00 ± 0.00a

Untreated

29.88 ± 0.13f

30.43 ± 0.13f

30.71 ± 0.13f

31.14 ± 0.00f

33.05 ± 0.00e

32.67 ± 0.03e

  1. Values were expressed as mean ± standard deviation (SD). Values with different superscripts (Alphabets) in a column are significantly different (p < 0.05) from each other. This implies that for each day, values with superscript (a) are the least value, followed by b then c, d e to f (highest). For example, at day 1, the lowest values for percentage parasitaemia were recorded in mice treated with artesunate + Ml followed by that of chloroquine while the highest parasitaemia was in untreated mice. These differences are statistically significant (all the values did not have similar superscript). At days 5 and 6, mice treated with artesunate and chloroquine have the least values for parasitaemia and both the same superscripts (a). This means they are not significantly different from one another. The opposite goes for mice treated with (artesunate + Mm) and (artesunate + Ml) at day 6. The former was significantly higher than the latter (p < 0.05) due to the fact that the two values share different superscripts (b and c)
  2. Mean values were from five mice observed in each group