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Table 2 Frequency of chromosomal abnormalities in mouse spermatocyte induced after treatment with CP and MEAC

From: Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide

Treatment and doses (mg/kg) Abnormal metaphases No. of different types of abnormal metaphases Inhibitory index
No. Mean (%) ± SE XY-uni. Auto.uni. XY-uni.+Auto.uni. Frag. Chain (IV)
I. Control 15 3.00 ± 0.48 9 6 0 0 0
II. CP (20) 85 17.00 ± 0.54a 50 28 3 1 3
III. MEAC (100) 18 3.60 ± 0.50 14 4 0 0 0
IV. MEAC (25 × 7 days) 22 4.40 ± 0.44 15 7 0 0 0
Single dose
 V. MEAC (25) + CP 78 15.60 ± 0.60a 54 21 2 0 1 10
 VI. MEAC (50) + CP 74 14.80 ± 0.50a 55 15 1 1 2 16
 VII. MEAC (100) + CP 62 12.40 ± 0.58ab 50 10 1 1 0 33
Repeated dose
 VIII. MEAC (25 × 3 days) + CP 73 14.60 ± 0.64a 50 20 2 0 1 18
IX. MEAC (25 × 7 days) + CP 58 11.60 ± 0.50ab 45 10 2 1 0 39
  1. Total number of examined metaphases 500 (100 metaphases/animal, 5 animals/group)
  2. The values having different superscript letters in each column are significantly different from one another as calculated by ANOVA.
  3. XY-uni XY-univalent, Auto.uni. autosomal univalent, XY-uni.+Auto.uni. XY-univalent + autosomal univalent, Frag. fragment