Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide

Bulletin of the National Research Centre

Table 2 Frequency of chromosomal abnormalities in mouse spermatocyte induced after treatment with CP and MEAC

Treatment and doses (mg/kg)	Abnormal metaphases		No. of different types of abnormal metaphases					Inhibitory index
Treatment and doses (mg/kg)	No.	Mean (%) ± SE	XY-uni.	Auto.uni.	XY-uni.+Auto.uni.	Frag.	Chain (IV)	Inhibitory index
I. Control	15	3.00 ± 0.48	9	6	0	0	0	–
II. CP (20)	85	17.00 ± 0.54^a	50	28	3	1	3	–
III. MEAC (100)	18	3.60 ± 0.50	14	4	0	0	0	–
IV. MEAC (25 × 7 days)	22	4.40 ± 0.44	15	7	0	0	0	–
Single dose
V. MEAC (25) + CP	78	15.60 ± 0.60^a	54	21	2	0	1	10
VI. MEAC (50) + CP	74	14.80 ± 0.50^a	55	15	1	1	2	16
VII. MEAC (100) + CP	62	12.40 ± 0.58^ab	50	10	1	1	0	33
Repeated dose
VIII. MEAC (25 × 3 days) + CP	73	14.60 ± 0.64^a	50	20	2	0	1	18
IX. MEAC (25 × 7 days) + CP	58	11.60 ± 0.50^ab	45	10	2	1	0	39

Total number of examined metaphases 500 (100 metaphases/animal, 5 animals/group)
The values having different superscript letters in each column are significantly different from one another as calculated by ANOVA.
XY-uni XY-univalent, Auto.uni. autosomal univalent, XY-uni.+Auto.uni. XY-univalent + autosomal univalent, Frag. fragment