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Table 1 Designed curcumin derivatives, their predicted antioxidant activities, and leverage values

From: Molecular design of curcumin analogues with potent antioxidant properties and thermodynamic evaluation of their mechanism of free radical scavenge

Comp No. Compound structure/name pIC50 Leverage
MCC 001 (1E, 4E)-1,5-bis(3-(aminomethyl)-4-hydroxyphenyl)penta-1,4-dien-3-one 5.097 0.602
MCC 002 (1E, 4E)-1,5-bis(4-hydroxy-3-((hydroxyamino)methyl)phenyl)penta-1,4-dien-3-one 4.131 0.556
MCC 003 (1E, 4E)-1,5-bis(4-hydroxy-3-((methylamino)methyl)phenyl)penta-1,4-dien-3-one 2.694 0.610
MCC 004 (1E, 4E)-1,5-bis(4-hydroxy-3-((hydroxyl (methyl)amino)methyl)phenyl)penta-1,4-dien-3-one 5.626 0.568
MCC 005 (1E,4E)-1-(3-(aminomethyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((hydroxyamino)methyl)phenyl)penta-1,4-dien-3-one 4.697 0.225
MCC 006 (1E,4E)-1-(3-((dimethylamino)methyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((hydroxyamino)methyl)phenyl)penta-1,4-dien-3-one 5.521 0.271
MCC 007 (1E,4E)-1-(3-(aminomethyl)-4-hydroxyphenyl)-5-(3-((dimethylamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one 6.334 0.386
MCC 008 (1E,4E)-1-(3-(aminomethyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((methylamino)methyl)phenyl)penta-1,4-dien-3-one 4.054 0.310
MCC 009 (1E,4E)-1-(3-(aminomethyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((hydroxy (methyl)amino)methyl)phenyl)penta-1,4-dien-3-one 6.475 0.236
MCC 010 (1E,4E)-1-(3-(aminomethyl)-4-hydroxyphenyl)-5-(3-((dihydroxyamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one 4.162 0.252
MCC 011 (1E,4E)-1-(3-(aminomethyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((methylamino)methyl)phenyl)penta-1,4-dien-3-one 4.343 0.162
MCC 012 (1E,4E)-1-(3-((dimethylamino)methyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((methylamino)methyl)phenyl)penta-1,4-dien-3-one 4.809 0.296
MCC 013 (1E,4E)-1-(3-(dihydroxyamino)methyl)-4-hydroxyphenyl)-5-(3-((dimethylamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one 4.62 0.253
MCC 014 (1E,4E)-1-(3-((dihydroxyamino)methyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((hydroxy (methyl)amino)methyl)phenyl)penta-1,4-dien-3-one 3.861 0.403
MCC 015 (1E,4E)-1-(3-((dimethylamino)methyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((hydroxy (methyl)amino)methyl)phenyl)penta-1,4-dien-3-one 6.282 0.344
MCC 016 (1E,4E)-1-(3-((dihydroxyamino)methyl)-4-hydroxyphenyl)-5-(4-hydroxy-3-((hydroxyamino)methyl)phenyl)penta-1,4-dien-3-one 3.144 0.397
MCC 017 (1E, 4E)-1,5-bis(3-((dihydroxyamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one 2.788 0.625