Potent bioactive methanolic extract of wild orange (Citrus macroptera Mont.) shows antioxidative, anti-inflammatory, and antimicrobial properties in in vitro, in vivo, and in silico studies

Bulletin of the National Research Centre

Table 1 Change in paw circumference (in mm) in different time intervals (in min) after the injection of carrageenan in the left hind paw of Wistar albino rats

Groups	Pre-injection	5 min	65 min	125 min	185 min	245 min	305 min	% of inhibition
Normal	33.19 ± 0.055	32.91 ± 0.24	32.50 ± 0.21	33.11 ± 0.54	32.70 ± 1.07	33.04 ± 0.04	32.10 ± 0.27
Low dose	31.89 ± 0.56	40.94 ± 1.45	40.68 ± 0.90	40.39 ± 0.94	39.49 ± 0.64	39.70 ± 0.59	38.97 ± 1.01**	39.94
High dose	33.59 ± 0.83	41.62 ± 0.65	41.28 ± 1.27	41.73 ± 1.29	39.91 ± 1.12	39.27 ± 0.68	37.00 ± 1.09***	71.07
Standard	32.80 ± 1.15	38.90 ± 1.92	37.56 ± 1.85	36.81 ± 1.39	36.78 ± 0.89	36.32 ± 0.17	34.80 ± 1.29***	83.03
Negative	32.38 ± 0.40	43.67 ± 1.43	43.76 ± 2.81	43.39 ± 1.74	45.83 ± 1.57	43.03 ± 1.15	44.17 ± 0.53

** = p < 0.01, *** = p < 0.001 when compared to normal negative control at the final hour of experiment, i.e., 6 h 5 min