Bulletin of the National Research Centre

Table 5 The distribution of genotype frequency of G-888C polymorphism of SDH gene in relation to severity (NPDR and PDR) of retinopathy in both genders

From: Role of advanced glycation end products and sorbitol dehydrogenase in the pathogenesis of diabetic retinopathy

		G-888C
Retinal state		GG		GC		CC		Pvalue
(Males)	No	12	80.0%	3	20.0%	0	0.0%	0.488
	NPDR	13	54.2%	10	41.7%	1	4.2%
	PDR	17	58.6%	10	34.5%	2	6.9%
(Females)	No	24	66.7%	10	27.8%	2	5.6%	0.932
	NPDR	19	59.4%	11	34.4%	2	6.3%
	PDR	22	64.7%	9	26.5%	3	8.8%

There was no statistically significant influence of the three genotypes (GG, GC, and CC) polymorphism on DR progression in both genders. However, there was an increased frequency of CC genotypes polymorphism with severity in both genders (0.0%, 4.2%, 6.9%) in males and (5.6%, 6.3%, 8.8%) in females

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