Role of advanced glycation end products and sorbitol dehydrogenase in the pathogenesis of diabetic retinopathy

Bulletin of the National Research Centre

Table 4 Distribution of genotype and alleles, and frequency of G-888C polymorphism of SDH gene in patients with and without DR

G888C		With retinopathy (n = 119)		Without retinopathy (n = 51)		OR	(95% CI)	P value
G888C		No.	%	No.	%	OR	(95% CI)	P value
Genotype	GG	71	59.7	36	70.6	1.62	(0.80–3.28)	0.18
	GC	40	33.6	13	25.5	0.68	(0.32–1.41)	0.30
	CC	8	6.7	2	3.9	0.57	(0.12–2.76)	0.48
Allele	G	182	76.5	85	83.3	1.54	(0.84–2.81)	0.16
Allele	C	56	23.5	17	16.7	0.65	(0.36–1.19)	0.16

There was no significant difference in the genotype distribution (C/C, G/C, and G/G) of the G˗888C polymorphism between the two groups of patients with DR and without DR. However, the CC genotype occurred more frequently in patients with DR than patients without DR (6.7% vs. 3.9%), and G/G genotype occurred more frequently in patients without DR than patients with DR (0.70.6 vs. 0.59.7)