Role of advanced glycation end products and sorbitol dehydrogenase in the pathogenesis of diabetic retinopathy

Bulletin of the National Research Centre

Table 3 Genotype frequency of C-1214G polymorphism of SDH gene in patients with and without DR

Allele		With retinopathy (n = 131)		Without retinopathy (n = 52)		OR	(95% CI)	P value
Specific		No.	%	No.	%	OR	(95% CI)	P value
Genotype	GG	31	25.2	11	21.2	0.80	(0.37–1.74)	0.57
	CG	69	56.1	37	71.2	1.93	(0.96–3.88)	0.06
	CC	23	18.7	4	7.7	0.36	(0.12–1.11)	0.07
Alleles	G	131	53.3	59	56.7	1.15	(0.73–1.83)	0.55
Alleles	C	115	46.7	45	43.3	0.87	(0.55–1.38)	0.55

There was no significant difference in the genotype distribution (C/C, C/G, G/G) of the C˗1214G polymorphism between the two groups of patients with and without DR. Also, there was no significant difference of G and C allele frequencies