Table 1 Demographic, ocular parameters, and genotyping of the two studied groups
Parameter | Glaucoma group (n = 50) | Control group (n = 50) | P value | |
|---|---|---|---|---|
Age* (years) | 55 ± 10 | 40 ± 11 | 0.72 | |
Sex | Male, n (%) | 21 (42) | 23 (46) | 0.68 |
Female, n (%) | 29 (58) | 27 (54) | ||
Rt visual acuity** | 0.4 (0.2–0.6) | 0.8 (0.7–1.0) | 0.001 | |
Lt visual acuity** | 0.4 (0.1–0.7) | 0.8 (0.6–1.0) | 0.001 | |
Rt IOP (mmHg)* | 19.4 ± 5.8 | 16 ± 2.1 | 0.004 | |
Lt IOP (mmHg)* | 19.3 ± 4.5 | 17 ± 2.2 | 0.003 | |
Rt cup to disc ratio** | 0.5 (0.4–0.7) | 0.3 (0.2–0.3) | 0.004 | |
Lt cup to disc ratio** | 0.5 (0.3–0.8) | 0.3 (0.2–0.4) | 0.001 | |
Rt mean deviation grade, n (%) | ||||
Mild, 0 to − 6 | 18 (36) | 0 (0) | ||
Moderate, − 6 to − 12 | 8 (16) | 0 (0) | ||
Severe, ≥ − 12 | 22 (44) | 0 (0) | ||
Blindness, optic atrophy | 2 (4) | 0 (0) | ||
Normal, no field changes | 0 (0) | 50 (100) | ||
Lt mean deviation grade, n (%) | ||||
Mild, 0 to − 6 | 22 (44) | 0 (0) | ||
Moderate, − 6 to − 12 | 6 (12) | 0 (0) | ||
Severe, ≥ − 12 | 19 (38) | 0 (0) | ||
Blindness, optic atrophy | 3 (6) | 0 (0) | ||
Normal, no field changes | 0 (0) | 50 (100) | ||
BDNF rs2030324 genotypes, n (%) | ||||
TT homozygous wild | 9 (18) | 11 (22) | ||
TC heterozygous | 30 (60) | 26 (52) | 0.722 | |
CC homozygous mutant | 11 (22) | 13 (26) | ||
Alleles, n (%) | ||||
T (n = 96) | 48 (48) | 48 (48) | 1.0 | |
C (n = 104) | 52 (52) | 52 (52) | ||