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Table 1 Demographic, ocular parameters, and genotyping of the two studied groups

From: Brain-derived neurotrophic factor (BDNF) gene polymorphism in a cohort of Egyptian primary open-angle glaucoma (POAG) patients

Parameter Glaucoma group (n = 50) Control group (n = 50) P value
Age* (years) 55 ± 10 40 ± 11 0.72
Sex Male, n (%) 21 (42) 23 (46) 0.68
Female, n (%) 29 (58) 27 (54)  
Rt visual acuity** 0.4 (0.2–0.6) 0.8 (0.7–1.0) 0.001
Lt visual acuity** 0.4 (0.1–0.7) 0.8 (0.6–1.0) 0.001
Rt IOP (mmHg)* 19.4 ± 5.8 16 ± 2.1 0.004
Lt IOP (mmHg)* 19.3 ± 4.5 17 ± 2.2 0.003
Rt cup to disc ratio** 0.5 (0.4–0.7) 0.3 (0.2–0.3) 0.004
Lt cup to disc ratio** 0.5 (0.3–0.8) 0.3 (0.2–0.4) 0.001
Rt mean deviation grade, n (%)    
 Mild, 0 to − 6 18 (36) 0 (0)  
 Moderate, − 6 to − 12 8 (16) 0 (0)  
 Severe, ≥ − 12 22 (44) 0 (0)  
 Blindness, optic atrophy 2 (4) 0 (0)  
 Normal, no field changes 0 (0) 50 (100)  
Lt mean deviation grade, n (%)    
 Mild, 0 to − 6 22 (44) 0 (0)  
 Moderate, − 6 to − 12 6 (12) 0 (0)  
 Severe, ≥ − 12 19 (38) 0 (0)  
 Blindness, optic atrophy 3 (6) 0 (0)  
 Normal, no field changes 0 (0) 50 (100)  
BDNF rs2030324 genotypes, n (%)    
 TT homozygous wild 9 (18) 11 (22)  
 TC heterozygous 30 (60) 26 (52) 0.722
 CC homozygous mutant 11 (22) 13 (26)  
Alleles, n (%)    
 T (n = 96) 48 (48) 48 (48) 1.0
 C (n = 104) 52 (52) 52 (52)  
  1. *Mean ± SD
  2. **Median (25th–75th percentile)