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Table 1 Description of studies identified as relevant in the systematic literature search looking for an association between T. gondii and diabetes mellitus

From: The association between Toxoplasma gondii and type 2 diabetes mellitus: a systematic review and meta-analysis of human case-control studies

Reference

Year published

Country

Diabetes

Study type

Source 1

Definition

Source 2

Matching*

Measure of exposure

Li et al. (Li et al. 2018)

2018

China

T1 + 2DM

CC

Hospital

Unspecified

Hospital

Yes

IgG/IgM ELISA (Demeditec Diagnostics, Germany)

Khalili et al. (Khalili et al. 2018)

2018

Iran

T1 + 2DM

CC

Clinics

Unspecified

Clinics

Yes

IgG/IgM CLIA (Disorin, Italy)

Han et al. (Han et al. 2018)

2018

China

T2DM

Case

Hospital

Yes

N/A

N/A

IgG ELISA (Haitai Biological Pharmaceuticals, China)

Molan & Ismail (Molan and Ismail 2017)

2017

Iraq

T1 + 2DM

CC

Clinics

Unspecified

Clinics

No

IgG/IgM ELISA (ACON Labs, USA)

Alvarado-Esquivel et al. (Alvarado-Esquivela et al. 2017)

2017

Brazil

T1 + 2DM

CC

Clinics

Unspecified

Clinics

Yes

IgG ELIFA & VIDAS ELFA IgM (BioMerieux, France)

Saheb (Saheb 2017)

2017

Iraq

T2DM

CC

Clinics

Unspecified

Clinics

No

IgG ELISA (BioCheck Inc., USA)

Nihad & Hamad (Nihad and Hamad 2017)

2017

Iraq

Diabetic

CC

Hospital

Unspecified

Hospital

No

IgG/IgM ELISA (BioCheck Inc., USA)

Hemida et al. (Hemida et al. 2017)

2017

Egypt

T1 + 2DM

Case

Hospital

Unspecified

N/A

N/A

IgG/IgM ELISA (Calbiotech Inc., USA)

Saki et al. (Saki and Shafieenia 2016)

2016

Iran

Diabetic

CC

Hospital

Unspecified

Hospital

No

IgG/IgM ELISA (Trinity Biotech, USA) & IFAT kit

Modrek et al. (Modrek et al. 2015a)

2015

Iran

Diabetic

Case

Hospital

Unspecified

N/A

N/A

IgG/IgM (DRG instrument GmbH, Germany)

Siyadatpanah et al. (Siyadatpanah et al. 2013)

2013

Iran

Diabetic

CC

Hospital

Unspecified

Hospital

Yes

IgG/IgM ELISA (VIRO, Germany)

Shirbazou et al. (Shirbazou et al. 2013)

2013

Iran

Diabetic

CC

Unspecified

Unspecified

Unspecified

Yes

IgG ELISA (Pishtaz Teb Zaman Diagnostics, Iran)

Gokce et al. (Gokce et al. 2008)

2008

Turkey

T2DM

CC

Unspecified

ADA

Unspecified

Yes

IgG/IgM ELISA and IFAT (Euroimmun)

  1. *Matching is by age and gender alone; source 1, source of diabetes mellitus cases; source 2, source of non-type 2 diabetes mellitus controls; definition, definition of diabetes mellitus cases. Highlight signifies the studies retained for the meta-analysis (Table 2)
  2. CC case-control, IgG immunoglobulin G, IgM immunoglobulin M, ELISA enzyme-linked immunosorbent assay, CLIA chemiluminescence immunoassay, ELIFA enzyme-linked immunofiltration assay, ELFA enzyme-linked fluorescent assay, IFAT immunofluorescence antibody test