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Table 4 Histopathological changes in the liver of rats exposed to TAA and the treatment effect of Ag-BSEPS, based on scoring severity of injury

From: Effect of nanopolysaccharide (BSEPS) from Bacillus subtilis sp. on thioacetamide-induced liver fibrosis in rats

Observation

Control (GI)

TAA (GII)

Ag-BSEPS (GIII)

TAA + Ag-BSEPS (GIV)

 Focal area in the degenerated hepatocytes

−

++++

-

+

 Congestion in the blood vessels

−

++++

−

++

 Inflammatory cells

−

++++

−

−

 Necrosis

_

++++

−

_

 Massive fibrosis

_

++++

_

_

 Hepatocytes degeneration

 

++++

_

_

  1. Normal (−), minimal (+), mild (++), severe (++++)