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Table 5 Multiple linear regression analysis showing the effect of confounding parameters on serum biomarkers in RVVI, RVVI types, and controls

From: Impaired PRR expression modulates inflammation-triggered oxidative stress and pathogenesis of recurrent vulvovaginal infections

MLR equations β-regression coefficients r F p
β1 p β2 p β3 p β4 p
RVVI
 sMBL = 421.126–2.500 X1 + 0.014 X2 + 19.33X3+9.688X4 − 0.039 0.541 0.001 0.981 0.135 0.034* 0.018 0.217 0.153 1.515 0.198
 sDectin-1 = 0.610+0.000 X1+0.000 X2–0.007X3–0.002X4 − 0.039 0.540 − 0.035 0.585 − 0.142 0.025* − 0.055 0.380 0.174 1.981 0.098
 sTAC = 1.445–0.003X1 + 0.000 X2–0.026X3 + 0.00X4 − 0.053 0.400 − 0.090 0.148 − 0.214 0.001*** − 0.005 0.940 0.258 4.526 0.002**
 sTOS = 19.13−0.053 X1–0.084 X2−0.181 X3–0.013 X4 − 0.057 0.375 0.000 0.994 − 0.088 0.169 − 0.008 0.906 0.113 0.824 0.511
 sOSI = 0.022 + 0.000 X1−0.0029 X2 + 0.096 X3 + 0.0495X4 0.049 0.454 − 0.005 0.935 0.016 0.802 0.009 0.885 0.005 0.191 0.943
BV
 sMBL = −141.73–2.692 X1 + 1.715 X2 + 38.78X3−15.87X4 − 0.051 0.622 0.076 0.452 0.323 0.003** − 0.128 0.229 0.317 2.562 0.044*
 sDectin-1 = 0.357−0.001 X1 + 0.002 X2–0.007X3–0.004X4 − 0.062 0.552 0.215 0.037* − 0.153 0.147 − 0.731 0.467 0.290 2.112 0.086
 sTAC = 1.727–0.004X1−0.002 X2–0.033X3 + 0.001X4 − 0.075 0.465 − 0.118 0.238 − 0.306 0.004** 0.007 0.950 0.352 3.247 0.015*
 sTOS = 23.349–0.117X1–0.034X2−0.122 X3–0.018 X4 − 0.139 0.198 − 0.093 0.371 − 0.063 0.556 − 0.009 0.935 0.199 0.952 0.438
 sOSI = 0.028 + 0.0241X1 + 0.000 X2 + 0.000 X3 + 0.000 X4 0.010 0.926 − 0.107 0.305 0.086 0.423 0.163 0.135 0.218 1.152 0.337
VVC
 sMBL = − 14.863 +2.938 X1−0.881 X2+23.468X3+39.35X4 0.053 0.676 − 0.091 0.484 0.204 0.109 0.393 0.002** 0.412 0.291 0.029*
 sDectin-1 = 0.944−0.007 X1+0.000 X2–0.013X3–0.005X4 − 0.311 0.013* − 0.077 0.541 − 0.272 0.029* − 0.134 0.264 0.466 3.950 0.007**
 sTAC = 1.797–0.003X1−0.001 X2–0.037X3 + 0.015X4 − 0.046 0.721 − 0.089 0.504 − 0.264 0.045* 0.126 0.322 0.342 1.885 0.126
 sTOS = 1.410 + 0.156 X1 + 0.023 X2 + 0.209 X3–0.011 X4 0.172 0.196 0.143 0.293 0.112 0.399 − 0.007 0.960 0.291 1.320 0.274
 sOSI = − 0.007 + 0.001 X1 + 0.027 X2 + 0.001 X3+0.000 X4 0.184 0.166 0.057 0.671 0.139 0.291 − 0.158 0.222 0.312 1.533 0.205
MI
 sMBL = − 894.80 + 0.254 X1−0.013 X2 + 85.56X3−21.53X4 0.003 0.987 − 0.002 0.992 0.422 0.007** − 0.181 0.233 0.492 2.880 0.036*
 sDectin-1 = 0.274+0.002 X1 + 0.000 X2 + 0.003X3–0.007X4 0.070 0.699 − 0.062 0.733 0.059 0.726 − 0.197 0.247 0.228 0.493 0.741
 sTAC = 1.117–0.004X1−0.001 X2–0.008X3 + 0.004X4 − 0.047 0.796 − 0.185 0.313 − 0.039 0.814 − 0.031 0.856 0.218 0.047 0.774
 sTOS = 35.73−0.296 X1−0.010 X2−0.760 X3 + 0.496 X4 − 0.224 0.166 − 0.096 0.548 − 0.280 0.062 0.311 0.040* 0.523 3.391 0.019*
 sOSI = 0.105 + 0.000 X1–0.098 X2–0.004 X3 + 0.000 X4 0.071 0.686 − 0.021 0.904 − 0.332 0.047* − 0.049 0.765 0.327 1.078 0.382
HC
 sMBL = 1885.16−9.76 X1−4.422 X2 + 6.967X3 − 0.099 0.166 − 0.065 0.362 0.036 0.619 0.114 0.870 0.458
 sDectin-1 = 0.204 + 0.000 X1 + 0.000 X2+0.001X3 0.036 0.618 − 0.072 0.071 0.030 0.026* 0.087 0.504 0.680
 sTAC = 0.847 + 0.003X1− 0.001 X2 + 0.005X3 0.038 0.596 − 0.023 0.743 0.033 0.646 0.058 0.225 0.879
 sTOS = 5.048−0.034 X1 + 0.154 X2 + 0.032 X3 − 0.024 0.738 0.155 0.030* 0.011 0.876 0.160 1.737 0.161
 sOSI = 0.029 + 0.000 X1 + 0.093 X2 + 0.0134X3 − 0.090 0.208 0.044 0.533 0.002 0.975 0.103 0.714 0.545
  1. X1 = age (years), X2 = RCBG (mg/dl), X3 = age of initiation of sexual activity (years), X4 = duration of infection (years); beta regression coefficients: β1 = age, β2 = RCBG, β3 = age of initiation of sexual activity, β4 = duration of infection; r = multiple correlation coefficient; *, **, and *** indicate significant at p ≤ 0.05, p ≤ 0.01, and p ≤ 0.001 respectively