Impaired PRR expression modulates inflammation-triggered oxidative stress and pathogenesis of recurrent vulvovaginal infections

Kalia, Namarta; Kaur, Manpreet; Sharma, Sujata; Singh, Jatinder

doi:10.1186/s42269-019-0147-1

Bulletin of the National Research Centre

Table 5 Multiple linear regression analysis showing the effect of confounding parameters on serum biomarkers in RVVI, RVVI types, and controls

From: Impaired PRR expression modulates inflammation-triggered oxidative stress and pathogenesis of recurrent vulvovaginal infections

MLR equations	β-regression coefficients								r	F	p
MLR equations	β₁	p	β₂	p	β₃	p	β₄	p	r	F	p
RVVI
sMBL = 421.126–2.500 X₁ + 0.014 X₂ + 19.33X₃+9.688X₄	− 0.039	0.541	0.001	0.981	0.135	0.034*	0.018	0.217	0.153	1.515	0.198
sDectin-1 = 0.610+0.000 X₁+0.000 X₂–0.007X₃–0.002X₄	− 0.039	0.540	− 0.035	0.585	− 0.142	0.025*	− 0.055	0.380	0.174	1.981	0.098
sTAC = 1.445–0.003X₁ + 0.000 X₂–0.026X₃ + 0.00X₄	− 0.053	0.400	− 0.090	0.148	− 0.214	0.001***	− 0.005	0.940	0.258	4.526	0.002**
sTOS = 19.13−0.053 X₁–0.084 X₂−0.181 X₃–0.013 X₄	− 0.057	0.375	0.000	0.994	− 0.088	0.169	− 0.008	0.906	0.113	0.824	0.511
sOSI = 0.022 + 0.000 X₁−0.0029 X₂ + 0.096 X₃ + 0.0495X₄	0.049	0.454	− 0.005	0.935	0.016	0.802	0.009	0.885	0.005	0.191	0.943
BV
sMBL = −141.73–2.692 X₁ + 1.715 X₂ + 38.78X₃−15.87X₄	− 0.051	0.622	0.076	0.452	0.323	0.003**	− 0.128	0.229	0.317	2.562	0.044*
sDectin-1 = 0.357−0.001 X₁ + 0.002 X₂–0.007X₃–0.004X₄	− 0.062	0.552	0.215	0.037*	− 0.153	0.147	− 0.731	0.467	0.290	2.112	0.086
sTAC = 1.727–0.004X₁−0.002 X₂–0.033X₃ + 0.001X₄	− 0.075	0.465	− 0.118	0.238	− 0.306	0.004**	0.007	0.950	0.352	3.247	0.015*
sTOS = 23.349–0.117X₁–0.034X₂−0.122 X₃–0.018 X₄	− 0.139	0.198	− 0.093	0.371	− 0.063	0.556	− 0.009	0.935	0.199	0.952	0.438
sOSI = 0.028 + 0.0241X₁ + 0.000 X₂ + 0.000 X₃ + 0.000 X₄	0.010	0.926	− 0.107	0.305	0.086	0.423	0.163	0.135	0.218	1.152	0.337
VVC
sMBL = − 14.863 +2.938 X₁−0.881 X₂+23.468X₃+39.35X₄	0.053	0.676	− 0.091	0.484	0.204	0.109	0.393	0.002**	0.412	0.291	0.029*
sDectin-1 = 0.944−0.007 X₁+0.000 X₂–0.013X₃–0.005X₄	− 0.311	0.013*	− 0.077	0.541	− 0.272	0.029*	− 0.134	0.264	0.466	3.950	0.007**
sTAC = 1.797–0.003X₁−0.001 X₂–0.037X₃ + 0.015X₄	− 0.046	0.721	− 0.089	0.504	− 0.264	0.045*	0.126	0.322	0.342	1.885	0.126
sTOS = 1.410 + 0.156 X₁ + 0.023 X₂ + 0.209 X₃–0.011 X₄	0.172	0.196	0.143	0.293	0.112	0.399	− 0.007	0.960	0.291	1.320	0.274
sOSI = − 0.007 + 0.001 X₁ + 0.027 X₂ + 0.001 X₃+0.000 X₄	0.184	0.166	0.057	0.671	0.139	0.291	− 0.158	0.222	0.312	1.533	0.205
MI
sMBL = − 894.80 + 0.254 X₁−0.013 X₂ + 85.56X₃−21.53X₄	0.003	0.987	− 0.002	0.992	0.422	0.007**	− 0.181	0.233	0.492	2.880	0.036*
sDectin-1 = 0.274+0.002 X₁ + 0.000 X₂ + 0.003X₃–0.007X₄	0.070	0.699	− 0.062	0.733	0.059	0.726	− 0.197	0.247	0.228	0.493	0.741
sTAC = 1.117–0.004X₁−0.001 X₂–0.008X₃ + 0.004X₄	− 0.047	0.796	− 0.185	0.313	− 0.039	0.814	− 0.031	0.856	0.218	0.047	0.774
sTOS = 35.73−0.296 X₁−0.010 X₂−0.760 X₃ + 0.496 X₄	− 0.224	0.166	− 0.096	0.548	− 0.280	0.062	0.311	0.040*	0.523	3.391	0.019*
sOSI = 0.105 + 0.000 X₁–0.098 X₂–0.004 X₃ + 0.000 X₄	0.071	0.686	− 0.021	0.904	− 0.332	0.047*	− 0.049	0.765	0.327	1.078	0.382
HC
sMBL = 1885.16−9.76 X₁−4.422 X₂ + 6.967X₃	− 0.099	0.166	− 0.065	0.362	0.036	0.619	–	–	0.114	0.870	0.458
sDectin-1 = 0.204 + 0.000 X₁ + 0.000 X₂+0.001X₃	0.036	0.618	− 0.072	0.071	0.030	0.026*	–	–	0.087	0.504	0.680
sTAC = 0.847 + 0.003X₁− 0.001 X₂ + 0.005X₃	0.038	0.596	− 0.023	0.743	0.033	0.646	–	–	0.058	0.225	0.879
sTOS = 5.048−0.034 X₁ + 0.154 X₂ + 0.032 X₃	− 0.024	0.738	0.155	0.030*	0.011	0.876	–	–	0.160	1.737	0.161
sOSI = 0.029 + 0.000 X₁ + 0.093 X₂ + 0.0134X₃	− 0.090	0.208	0.044	0.533	0.002	0.975	–	–	0.103	0.714	0.545

X₁ = age (years), X₂ = RCBG (mg/dl), X₃ = age of initiation of sexual activity (years), X₄ = duration of infection (years); beta regression coefficients: β1 = age, β2 = RCBG, β₃ = age of initiation of sexual activity, β₄ = duration of infection; r = multiple correlation coefficient; *, **, and *** indicate significant at p ≤ 0.05, p ≤ 0.01, and p ≤ 0.001 respectively

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