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Table 4 Multiple linear regression analysis of serum biomarkers in RVVI, RVVI types and controls

From: Impaired PRR expression modulates inflammation-triggered oxidative stress and pathogenesis of recurrent vulvovaginal infections

MLR equations β-regression coefficients r F p
β1 p β2 p β3 p β4 p
RVVI
 sMBL = 953.8 + 52.39XDec−290.95XTAC + 6.24XTOS − 314.89XOSI 0.018 0.772 − 0.218 0.006** 0.090 0.217 − 0.137 0.101 0.173 1.954 0.102
 sDectin-1 = 0.315 + 0.0063XMBL + 0.095XTAC+0.001XTOS+0.219XOSI 0.018 0.772 0.227 0.004** 0.041 0.566 0.027 0.744 0.224 3.32 0.010**
 sTAC = 0.725+0.000XMBL+0.343XDec+ 0.020XTOS−11.89XOSI − 0.136 0.006** 0.145 0.004** 0.340 0.000*** − 0.619 0.000*** 0.629 41.32 0.000***
 sTOS = 1.940+0.001XMBL+1.293XDec+7.012XTAC+196.09XOSI 0.067 0.217 0.032 0.566 0.406 0.000*** 0.592 0.000*** 0.526 24.23 0.000***
 sOSI = 0.032−0.003XMBL+0.002XDec−0.029XTAC+0.001XTOS − 0.077 0.101 0.016 0.144 − 0.561 0.000*** 0.449 0.000*** 0.672 52.12 0.000***
BV
 sMBL = 808.15 + 180.75XDec − 153.73XTAC + 2.141XTOS−1854.2XOSI 0.071 0.506 − 0.137 0.282 0.034 0.763 − 0.086 0.502 0.122 0.346 0.846
 sDectin-1 = 0.263 + 0.026XMBL + 0.123XTAC−0.002XTOS + 0.851XOSI 0.068 0.506 0.280 0.023* − 0.070 0.527 0.100 0.422 0.243 1.445 0.225
 sTAC = 0.639 − 0.081XMBL + 0.445XDec + 0.016XTOS−10.351XOSI − 0.092 0.282 0.196 0.023* 0.287 0.002** − 0.535 0.000*** 0.584 11.924 0.000***
 sTOS = 5.283 + 0.000XMBL − 2.537XDec + 6.512XTAC + 150.14XOSI 0.029 0.763 − 0.062 0.527 0.363 0.002** 0.433 0.000*** 0.409 4.625 0.002**
 sOSI = 0.033−0.0026XMBL + 0.008XDec−0.028XTAC + 0.001XTOS − 0.057 0.502 0.070 0.422 − 0.537 0.000*** 0.343 0.000*** 0.583 11.82 0.000***
VVC
 sMBL = 786.07−425.19XDec−121.667XTAC + 10.41XTOS−1782.2XOSI − 0.173 0.218 − 0.147 0.394 0.169 0.307 − 0.088 0.638 0.251 0.960 0.437
 sDectin-1 = 0.368−0.062XMBL+0.092XTAC+ 0.003XTOS−1.151XOSI − 0.153 0.218 0.273 0.090 0.100 0.520 − 0.140 0.426 0.416 2.983 0.026*
 sTAC = 0.676 + 0.000XMBL + 0.539XDec + 0.032XTOS−15.46XOSI − 0.087 0.394 − 0.181 0.090 0.428 0.000*** − 0.631 0.000*** 0.671 11.66 0.000***
 sTOS = − 0.416 + 0.002XMBL + 2.898XDec + 6.268XTAC + 227.099XOSI 0.108 0.307 0.073 0.520 0.469 0.000*** 0.693 0.000*** 0.631 9.447 0.000***
 sOSI = 0.028−0.0021XMBL−0.010XDec−0.022XTAC + 0.002XTOS − 0.044 0.638 − 0.080 0.426 − 0.542 0.000*** 0.544 0.000*** 0.727 15.95 0.000***
MI
 sMBL = 1101.84 + 294.18XDec−164.99XTAC−18.93XTOS−1980.7XOSI 0.085 0.606 − 0.159 0.497 − 0.254 0.184 − 0.117 0.593 0.342 1.195 0.330
 sDectin-1 = 0.239 + 0.0254XMBL + 0.122XTAC−0.002XTOS + 1.105XOSI 0.088 0.606 0.406 0.082 − 0.071 0.719 0.225 0.308 0.301 0.898 0.476
 sTAC = 0.449−0.078XMBL + 0.668XDec + 0.029XTOS−10.389XOSI − 0.081 0.497 0.201 0.082 0.398 0.002** − 0.636 0.000*** 0.742 11.01 0.000***
 sTOS = 6.754−0.003XMBL−2.384XDec + 8.172XTAC+111.79XOSI − 0.191 0.184 − 0.052 0.719 0.588 0.002** 0.492 0.006** 0.580 4.55 0.004**
 sOSI = 0.034−0.004XMBL+0.026XDec−0.045XTAC+0.002XTOS − 0.539 0.593 1.034 0.308 − 5.595 0.000*** 2.893 0.006** 0.695 8.387 0.000***
HC
 sMBL = 847.39−326.7XDec + 112.62XTAC + 12.81XTOS + 4266.3XOSI − 0.039 0.582 0.082 0.351 0.181 0.035* 0.132 0.209 0.275 4.05 0.004**
 sDectin-1 = 0.233−0.0046XMBL−0.046XTAC + 0.000XTOS−0.208XOSI − 0.039 0.582 − 0.282 0.001*** − 0.043 0.631 − 0.054 0.610 0.266 3.750 0.006**
 sTAC = 1.284 + 0.039XMBL−1.116XDec + 0.013XTOS−16.59XOSI 0.053 0.351 − 0.182 0.001*** 0.266 0.000*** − 0.704 0.000*** 0.632 32.88 0.000***
 sTOS = 4.316 + 0.002XMBL−3.321XDec + 5.183XTAC + 333.820XOSI 0.119 0.035* − 0.027 0.631 0.259 0.000*** 0.707 0.000*** 0.644 34.99 0.000***
 sOSI = 0.026 + 0.018XMBL−0.006XDec−0.021XTAC + 0.001XTOS 0.060 0.209 − 0.024 0.610 − 0.493 0.000 0.508 0.000*** 0.761 68.09 0.000***
  1. XMBL = sMBL (ng/ml), XDec = sDectin-1 (ng/ml), XTAC = TAC (mmol Trolox Equiv/L), XTOS = TOS (μmol H2O2 Equiv/L), XOSI = OSI (arbitrary unit); beta regression coefficients:β1, β2, β3, β4 respectively based on X variables given in MLR equations; r = multiple correlation coefficient; *, **, and *** indicate significant at p ≤ 0.05, p ≤ 0.01, and p ≤ 0.001 respectively