Impaired PRR expression modulates inflammation-triggered oxidative stress and pathogenesis of recurrent vulvovaginal infections

Kalia, Namarta; Kaur, Manpreet; Sharma, Sujata; Singh, Jatinder

doi:10.1186/s42269-019-0147-1

Bulletin of the National Research Centre

Table 4 Multiple linear regression analysis of serum biomarkers in RVVI, RVVI types and controls

From: Impaired PRR expression modulates inflammation-triggered oxidative stress and pathogenesis of recurrent vulvovaginal infections

MLR equations	β-regression coefficients								r	F	p
MLR equations	β₁	p	β₂	p	β₃	p	β₄	p	r	F	p
RVVI
sMBL = 953.8 + 52.39X_Dec−290.95X_TAC + 6.24X_TOS − 314.89X_OSI	0.018	0.772	− 0.218	0.006**	0.090	0.217	− 0.137	0.101	0.173	1.954	0.102
sDectin-1 = 0.315 + 0.0063X_MBL + 0.095X_TAC+0.001X_TOS+0.219X_OSI	0.018	0.772	0.227	0.004**	0.041	0.566	0.027	0.744	0.224	3.32	0.010**
sTAC = 0.725+0.000X_MBL+0.343X_Dec+ 0.020X_TOS−11.89X_OSI	− 0.136	0.006**	0.145	0.004**	0.340	0.000***	− 0.619	0.000***	0.629	41.32	0.000***
sTOS = 1.940+0.001X_MBL+1.293X_Dec+7.012X_TAC+196.09X_OSI	0.067	0.217	0.032	0.566	0.406	0.000***	0.592	0.000***	0.526	24.23	0.000***
sOSI = 0.032−0.003X_MBL+0.002X_Dec−0.029X_TAC+0.001X_TOS	− 0.077	0.101	0.016	0.144	− 0.561	0.000***	0.449	0.000***	0.672	52.12	0.000***
BV
sMBL = 808.15 + 180.75X_Dec − 153.73X_TAC + 2.141X_TOS−1854.2X_OSI	0.071	0.506	− 0.137	0.282	0.034	0.763	− 0.086	0.502	0.122	0.346	0.846
sDectin-1 = 0.263 + 0.026X_MBL + 0.123X_TAC−0.002X_TOS + 0.851X_OSI	0.068	0.506	0.280	0.023*	− 0.070	0.527	0.100	0.422	0.243	1.445	0.225
sTAC = 0.639 − 0.081X_MBL + 0.445X_Dec + 0.016X_TOS−10.351X_OSI	− 0.092	0.282	0.196	0.023*	0.287	0.002**	− 0.535	0.000***	0.584	11.924	0.000***
sTOS = 5.283 + 0.000X_MBL − 2.537X_Dec + 6.512X_TAC + 150.14X_OSI	0.029	0.763	− 0.062	0.527	0.363	0.002**	0.433	0.000***	0.409	4.625	0.002**
sOSI = 0.033−0.0026X_MBL + 0.008X_Dec−0.028X_TAC + 0.001X_TOS	− 0.057	0.502	0.070	0.422	− 0.537	0.000***	0.343	0.000***	0.583	11.82	0.000***
VVC
sMBL = 786.07−425.19X_Dec−121.667X_TAC + 10.41X_TOS−1782.2X_OSI	− 0.173	0.218	− 0.147	0.394	0.169	0.307	− 0.088	0.638	0.251	0.960	0.437
sDectin-1 = 0.368−0.062X_MBL+0.092X_TAC+ 0.003X_TOS−1.151X_OSI	− 0.153	0.218	0.273	0.090	0.100	0.520	− 0.140	0.426	0.416	2.983	0.026*
sTAC = 0.676 + 0.000X_MBL + 0.539X_Dec + 0.032X_TOS−15.46X_OSI	− 0.087	0.394	− 0.181	0.090	0.428	0.000***	− 0.631	0.000***	0.671	11.66	0.000***
sTOS = − 0.416 + 0.002X_MBL + 2.898X_Dec + 6.268X_TAC + 227.099X_OSI	0.108	0.307	0.073	0.520	0.469	0.000***	0.693	0.000***	0.631	9.447	0.000***
sOSI = 0.028−0.0021X_MBL−0.010X_Dec−0.022X_TAC + 0.002X_TOS	− 0.044	0.638	− 0.080	0.426	− 0.542	0.000***	0.544	0.000***	0.727	15.95	0.000***
MI
sMBL = 1101.84 + 294.18X_Dec−164.99X_TAC−18.93X_TOS−1980.7X_OSI	0.085	0.606	− 0.159	0.497	− 0.254	0.184	− 0.117	0.593	0.342	1.195	0.330
sDectin-1 = 0.239 + 0.0254X_MBL + 0.122X_TAC−0.002X_TOS + 1.105X_OSI	0.088	0.606	0.406	0.082	− 0.071	0.719	0.225	0.308	0.301	0.898	0.476
sTAC = 0.449−0.078X_MBL + 0.668X_Dec + 0.029X_TOS−10.389X_OSI	− 0.081	0.497	0.201	0.082	0.398	0.002**	− 0.636	0.000***	0.742	11.01	0.000***
sTOS = 6.754−0.003X_MBL−2.384X_Dec + 8.172X_TAC+111.79X_OSI	− 0.191	0.184	− 0.052	0.719	0.588	0.002**	0.492	0.006**	0.580	4.55	0.004**
sOSI = 0.034−0.004X_MBL+0.026X_Dec−0.045X_TAC+0.002X_TOS	− 0.539	0.593	1.034	0.308	− 5.595	0.000***	2.893	0.006**	0.695	8.387	0.000***
HC
sMBL = 847.39−326.7X_Dec + 112.62X_TAC + 12.81X_TOS + 4266.3X_OSI	− 0.039	0.582	0.082	0.351	0.181	0.035*	0.132	0.209	0.275	4.05	0.004**
sDectin-1 = 0.233−0.0046X_MBL−0.046X_TAC + 0.000X_TOS−0.208X_OSI	− 0.039	0.582	− 0.282	0.001***	− 0.043	0.631	− 0.054	0.610	0.266	3.750	0.006**
sTAC = 1.284 + 0.039X_MBL−1.116X_Dec + 0.013X_TOS−16.59X_OSI	0.053	0.351	− 0.182	0.001***	0.266	0.000***	− 0.704	0.000***	0.632	32.88	0.000***
sTOS = 4.316 + 0.002X_MBL−3.321X_Dec + 5.183X_TAC + 333.820X_OSI	0.119	0.035*	− 0.027	0.631	0.259	0.000***	0.707	0.000***	0.644	34.99	0.000***
sOSI = 0.026 + 0.018X_MBL−0.006X_Dec−0.021X_TAC + 0.001X_TOS	0.060	0.209	− 0.024	0.610	− 0.493	0.000	0.508	0.000***	0.761	68.09	0.000***

X_MBL = sMBL (ng/ml), X_Dec = sDectin-1 (ng/ml), X_TAC = TAC (mmol Trolox Equiv/L), X_TOS = TOS (μmol H₂O₂ Equiv/L), X_OSI = OSI (arbitrary unit); beta regression coefficients:β₁, β₂, β₃, β₄ respectively based on X variables given in MLR equations; r = multiple correlation coefficient; *, **, and *** indicate significant at p ≤ 0.05, p ≤ 0.01, and p ≤ 0.001 respectively

Back to article page