Skip to main content

Table 2 Examples of natural chemosensitizers of ABC transporters isolated from plants

From: Targeting multidrug resistance in cancer by natural chemosensitizers

Targeted ABC transporter

Chemosensitizer

Reference

ABCB1/P-gp/MDR-1

5-Bromotetrandrine

(Jin et al. 2005)

Abietane diterpene

(Madureira et al. 2004a)

Alisol B 23-acetate

(Wang et al. 2004a)

Amooranin

(Ramachandran et al. 2003)

Baicalein and derivatives

(Lee et al. 2004)

Biochanin A

(Zhang and Morris 2003)

Bitter melon extract

(Limtrakul et al. 2004)

Bufalin

(Mahringer et al. 2010)

Cannabinoids

(Zhu et al. 2006; Holland et al. 2006)

β-Carotene

(Teng et al. 2016)

Catechins

(Kitagawa et al. 2004)

Cepharanthine

(Koizumi et al. 1995)

Coumarins

(Raad et al. 2006)

Curcumin and semisynthetic derivatives

(Chearwae et al. 2004; Anuchapreeda et al. 2002; Ooko et al. 2016)

Cycloartanes

(Madureira et al. 2004b)

Deoxyschizandrin

(Yoo et al. 2007)

Didehydrostemofolines

(Umsumarng et al. 2017)

Eudesmin

(Lim et al. 2007)

Euphocharacins A-L

(Corea et al. 2004)

Ginkgo biloba extract

(Nabekura et al. 2008; Fan et al. 2009)

Ginsenoside Rg

(Kim et al. 2003)

Grapefruit juice extracts

(de Castro et al. 2007)

Hapalosin

(Palomo et al. 2004)

Hypericin and hyperforin

(Wang et al. 2004b)

Isoquinoline alkaloid, isotetrandrine

(Wang and Yang 2008)

Isostemofoline

(Umsumarng et al. 2017)

Jatrophanes

(Hohmann et al. 2003; Reis et al. 2016)

Kaempferia parviflora extracts

(Patanasethanont et al. 2007a)

Kavalactones

(Weiss et al. 2005)

Morin

(Zhang and Morris 2003)

Ningalin B and derivatives

(Soenen et al. 2003; Tao et al. 2004)

Opiates

(Hemauer et al. 2009)

Phloretin

(Zhang and Morris 2003)

Piperine

(Han et al. 2008)

Polyoxypregnanes

(KKW et al. 2017)

Protopanaxatriol ginsenosides

(Choi et al. 2003)

Pyranocoumarins

(Wu et al. 2003)

Quercetin

(Limtrakul et al. 2005; Scambia et al. 1994)

Schisandrol A

(Fong et al. 2007)

Sesquiterpenes

(Munoz-Martinez et al. 2004)

Silymarin

(Zhang and Morris 2003)

Sinensetin

(Choi et al. 2002)

Stemona curtisii root extract

(Limtrakul et al. 2007a)

Taxane derivatives

(Brooks et al. 2004; Zhao et al. 2004)

Terpenoids

(Yoshida et al. 2006)

Tetrandine

(Fu et al. 2004)

Vitamin E TPGS

(Collnot et al. 2007)

ABCG2/BCRP/MXR

3′-4′-7-Trimethoxyflavone

(Katayama et al. 2007)

6-Prenylchrysin

(Ahmed-Belkacem et al. 2005)

Acacetin

(Imai et al. 2004)

Biochanin A

(Zhang et al. 2004)

Cannabinoids

(Holland et al. 2007)

Chrysin

(Zhang et al. 2004)

Curcumin

(Chearwae et al. 2006a)

Daizein

(Cooray et al. 2004)

Eupatin

(Henrich et al. 2006)

Genistein

(Imai et al. 2004)

Ginsenosides

(Jin et al. 2006)

Harmine

(Ma and Wink 2010)

Hesperetin

(Cooray et al. 2004)

Kaempferol

(Imai et al. 2004)

Naringenin

(Imai et al. 2004)

Plumbagin

(Shukla et al. 2007)

Quercetin

(Cooray et al. 2004)

Resveratrol

(Cooray et al. 2004)

Rotenoids

(Ahmed-Belkacem et al. 2007)

Silymarin

(Cooray et al. 2004)

Stilbenoids

(Morita et al. 2005)

Tectochrysin

(Ahmed-Belkacem et al. 2005)

Terpenoids

(Yoshida et al. 2008)

Tetrahydrocurcumin

(Limtrakul et al. 2007b)

ABCC1/MRP1

Cannabinoids

(Holland et al. 2008)

Cepharanthine

(Abe et al. 1995)

Curcumin

(Chearwae et al. 2006b)

Ginkgo biloba extract

(Nabekura et al. 2008)

Kaempferia parviflora extracts

(Patanasethanont et al. 2007b)

Myricetin

(van Zanden et al. 2005)

Quercetin

(Leslie et al. 2001; Wu et al. 2005)

Stemona curtisii root extract

(Limtrakul et al. 2007a)