Table 1 Families of human ABC transporters and their functions. Data were adapted from Vasiliou et al. (2009)
From: Targeting multidrug resistance in cancer by natural chemosensitizers
ABC transporter family | ABC transporter | Major function |
|---|---|---|
ABCA | ABCA1 | Efflux of cholesterol |
ABCA2 | MDR | |
ABCA3 | ||
ABCA4 | Efflux of N-retinylidene-phosphatidylethanolamine (PE) | |
ABCA5 | Urinary diagnostic marker for prostatic intraepithelial neoplasia (PIN) | |
ABCA6 | MDR | |
ABCA7 | Efflux of Cholesterol | |
ABCA8 | Transports of some lipophilic drugs | |
ABCA9 | Might play a role in monocyte differentiation and macrophage lipid homeostasis | |
ABCA10 | Cholesterol-responsive gene | |
ABCA12 | Has implications for prenatal diagnosis | |
ABCA13 | Inherited disorder affecting the pancreas | |
ABCB | ABCB1 | MDR |
ABCB2-TAP1 | Peptide transport | |
ABCB3-TAP2 | Peptide transport | |
ABCB4 | Phosphatidylcholine (PC) transport | |
ABCB5 | Melanogenesis | |
ABCB6 | Iron transport | |
ABCB7 | Fe/S cluster transport | |
ABCB8 | Intracellular peptide trafficking across membranes | |
ABCB9 | Located in lysosomes | |
ABCB10 | Export of peptides derived from proteolysis of inner-membrane proteins | |
ABCB11 | Bile salt transport | |
ABCC | ABCC1 | MDR |
ABCC2 | Organic anion efflux | |
ABCC3 | MDR | |
ABCC4 | Nucleoside transport | |
ABCC5 | Nucleoside transport | |
ABCC6 | Expressed primarily in liver and kidney | |
ABCC7-CFTR | Chloride ion channel (same as CFTR gene in cystic fibrosis) | |
ABCC8 | Sulfonylurea receptor | |
ABCC9 | Encodes the regulatory SUR2A subunit of the cardiac K(ATP)channel | |
ABCC10 | MDR, xenobiotic efflux | |
ABCC11 | ||
ABCC12 | ||
ABCC13 | Encodes a polypeptide of unknown function | |
ABCD | ABCD1 | Transport of Very long chain fatty acid (VLCFA) |
ABCD2 | Major modifier locus for clinical diversity in X linked ALD (X-ALD) | |
ABCD3 | Involved in import of fatty acids and/or fatty acyl coenzyme as into the peroxisome | |
ABCD4 | May modify the ALD phenotype | |
ABCE | ABCE1 | Oligoadenylate-binding protein |
ABCF | ABCF1 | Susceptibility to autoimmune pancreatitis |
ABCF2 | Tumor suppression at metastatic sites and in endocrine pathway for breast cancer/drug resistance | |
ABCF3 | Also present in promastigotes (one of five forms in the life cycle of trypanosomes) | |
ABCG | ABCG1 | Cholesterol transport |
ABCG2 | MDR, xenobiotic efflux | |
ABCG4 | Found in macrophage, eye, brain and spleen | |
ABCG5 | Sterol transport | |
ABCG8 | Sterol transport |