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Table 3 Effect of daily caffeine treatment (30 mg/kg) on the levels of lipid peroxidation (MDA) (nmol/g), reduced glutathione (GSH) (mmol/g), and nitric oxide (NO) (μmol/g) in the cortex and hippocampus of rat model of depression induced by reserpine

From: Assessment of the antidepressant effect of caffeine using rat model of depression induced by reserpine

  Control Depressed rat model % D Depressed rats treated with caffeine %D p value
Cortex MDA 7.326a ± 0.786 (6) 10.373b ± 1.147 (6) 41.59 7.687a ± 0.792 (6) 4.93 0.027
GSH 6.445a ± 0.138 (7) 6.080a ± 0.280 (7) − 5.66 7.093b ± 0.226 (7) 10.05 0.026
NO 0.194a ± 0.016 (6) 0.240b ± 0.014 (6) 23.71 0.272b ± 0.013 (7) 40.21 0.010
Hippocampus MDA 5.046a ± 0.798 (6) 9.827b ± 1.895 (6) 78.25 4.516a ± 1.033 (6) − 10.50 0.008
GSH 15.406a ± 0.328 (6) 13.031b ± 0.531 (6) − 15.42 15.879a ± 0.625 (7) 3.07 0.015
NO 0.459a ± 0.044 (6) 0.825b ± 0.082 (6) 79.74 0.564ab ± 0.039 (7) 22.87 0.010
  1. Values represent mean ± S.E. with the number of animals between parentheses
  2. % D difference with respect to control values
  3. Different letters indicate significantly different means p value < 0.05
  4. Same letters indicate nonsignificant changes