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Table 2 Effect of daily caffeine treatment (30 mg/kg) on the activity of acetylcholinesterase (AchE) (μmol SH/g/min) and Na, k, ATPase (μmol Pi/min/g) in the cortex and hippocampus of rat model of depression induced by reserpine

From: Assessment of the antidepressant effect of caffeine using rat model of depression induced by reserpine

 

Control

Depressed rat model

% D

Depressed rats treated with caffeine

%D

p value

Cortex

AchE

3.307a ± 0.772 (6)

7.080b ± 0.546 (6)

114.1

5.495b ± 0.031 (6)

66.16

0.011

Na, K, ATPase

0.181a ± 0.010 (6)

0.249b ± 0.021 (6)

37.57

0.174a ± 0.010 (6)

− 3.87

0.018

Hippocampus

AchE

6.047a ± 1.588 (6)

11.084b ± 1.390 (7)

83.29

9.18c ± 0.505 (6)

51.89

0.027

Na, K, ATPase

0.523a ± 0.024 (6)

0.680b ± 0.081 (6)

30.02

0.493a ± 0.019 (7)

− 5.73

0.018

  1. Values represent mean ± S.E. with the number of animals between parentheses
  2. % D difference with respect to control values
  3. Different letters indicate significantly different means p value < 0.05
  4. Same letters indicate nonsignificant changes