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Table 2 Effect of daily caffeine treatment (30 mg/kg) on the activity of acetylcholinesterase (AchE) (μmol SH/g/min) and Na, k, ATPase (μmol Pi/min/g) in the cortex and hippocampus of rat model of depression induced by reserpine

From: Assessment of the antidepressant effect of caffeine using rat model of depression induced by reserpine

  Control Depressed rat model % D Depressed rats treated with caffeine %D p value
Cortex AchE 3.307a ± 0.772 (6) 7.080b ± 0.546 (6) 114.1 5.495b ± 0.031 (6) 66.16 0.011
Na, K, ATPase 0.181a ± 0.010 (6) 0.249b ± 0.021 (6) 37.57 0.174a ± 0.010 (6) − 3.87 0.018
Hippocampus AchE 6.047a ± 1.588 (6) 11.084b ± 1.390 (7) 83.29 9.18c ± 0.505 (6) 51.89 0.027
Na, K, ATPase 0.523a ± 0.024 (6) 0.680b ± 0.081 (6) 30.02 0.493a ± 0.019 (7) − 5.73 0.018
  1. Values represent mean ± S.E. with the number of animals between parentheses
  2. % D difference with respect to control values
  3. Different letters indicate significantly different means p value < 0.05
  4. Same letters indicate nonsignificant changes