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Table 1 Effect of daily caffeine treatment (30 mg/kg) on the level of serotonin (μg/g), norepinephrine (μg/g), and dopamine (μg/g) in the cortex and hippocampus of rat model of depression induced by reserpine

From: Assessment of the antidepressant effect of caffeine using rat model of depression induced by reserpine

 

Control

Depressed rat model

% D

Depressed rats treated with caffeine

%D

p value

Cortex

Serotonin

0.166a ± 0.027 (6)

0.074b ± 0.008 (7)

− 55.30

0.104b ± 0.013 (7)

− 37.34

009

Norepinephrine

0.155a ± 0.004 (6)

0.129b ± 0.003 (7)

− 14.57

0.160a ± 0.009 (7)

5.96

0.028

Dopamine

0.904a ± 0.074 (6)

0.713a ± 0.066 (6)

− 21.12

0.850a ± 0.052 (7)

− 5.97

0.151

Hippocampus

Serotonin

0.526a ± 0.074 (6)

0.231b ± 0.031 (6)

− 48.20

0.581a ± 0.087 (6)

10.45

0.008

Norepinephrine

0.477a ± 0.095 (6)

0.258b ± 0.030 (6)

− 45.91

0.537a ± 0.081 (6)

12.57

0.026

Dopamine

1.220a ± 0.078 (6)

0.790b ± 0.043 (6)

− 35.24

1.468a ± 0.073 (6)

20.32

0.004

  1. Values represent mean ± S.E. with the number of animals between parentheses
  2. % D difference with respect to control values
  3. Different letters indicate significantly different means p value < 0.05
  4. Same letters indicate nonsignificant changes