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Table 1 Effect of daily caffeine treatment (30 mg/kg) on the level of serotonin (μg/g), norepinephrine (μg/g), and dopamine (μg/g) in the cortex and hippocampus of rat model of depression induced by reserpine

From: Assessment of the antidepressant effect of caffeine using rat model of depression induced by reserpine

  Control Depressed rat model % D Depressed rats treated with caffeine %D p value
Cortex Serotonin 0.166a ± 0.027 (6) 0.074b ± 0.008 (7) − 55.30 0.104b ± 0.013 (7) − 37.34 009
Norepinephrine 0.155a ± 0.004 (6) 0.129b ± 0.003 (7) − 14.57 0.160a ± 0.009 (7) 5.96 0.028
Dopamine 0.904a ± 0.074 (6) 0.713a ± 0.066 (6) − 21.12 0.850a ± 0.052 (7) − 5.97 0.151
Hippocampus Serotonin 0.526a ± 0.074 (6) 0.231b ± 0.031 (6) − 48.20 0.581a ± 0.087 (6) 10.45 0.008
Norepinephrine 0.477a ± 0.095 (6) 0.258b ± 0.030 (6) − 45.91 0.537a ± 0.081 (6) 12.57 0.026
Dopamine 1.220a ± 0.078 (6) 0.790b ± 0.043 (6) − 35.24 1.468a ± 0.073 (6) 20.32 0.004
  1. Values represent mean ± S.E. with the number of animals between parentheses
  2. % D difference with respect to control values
  3. Different letters indicate significantly different means p value < 0.05
  4. Same letters indicate nonsignificant changes