Fig. 4
a Kidney section of control rats showed normal glomeruli. b Kidney section of control rats treated with plant seeds carbohydrate showed renal cortex and renal corpuscle with normal glomerulus (red arrow), normal pattern of proximal convoluted (black arrow), and distal convoluted (yellow arrow) tubules. c Kidney section of control rats treated with plant seeds oil showed few of the glomeruli corpuscles are collapsed and atrophic (red arrow). Proximal convoluted tubules showed destructed epithelial lining (black arrow), destructed epithelial lining of distal convoluted tubules (yellow arrow). d Kidney section of ketoprofen-induced rats showed few of glomeruli corpuscles (hyperplasia of epithelial cells lining the partial layer of Bowman’s capsule) (red arrow), proximal and distal convoluted tubules with destruction of the epithelial lining cells (black and yellow arrow), many interstitial epithelial cells with cytoplasmic vacuoles and eccentric nuclei (green arrow). e Kidney section of ketoprofen rats treated with plant seed carbohydrate showed renal cortex and renal corpuscle with almost normal glomerulus (red arrow), almost normal pattern of proximal convoluted (black arrow), and distal convoluted (yellow arrow) tubules. f Kidney section of ketoprofen rats treated with plant seeds oil showed renal cortex showing renal corpuscle with normal glomerulus (red arrow), normal pattern of proximal convoluted (black arrow), and distal convoluted (yellow arrow) tubules. g Kidney section of ketoprofen rats treated with silymarin showed renal cortex and renal corpuscle with almost normal glomerulus (red arrow), normal pattern of proximal convoluted (black arrow), and distal convoluted (yellow arrow) tubules (H&E, × 200, × 400)