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Table 1 Prophylactic and therapeutic effect of chitosan on renal functions against Li2CO3 induced renal toxicity in rats

From: A renoprotective role of chitosan against lithium-induced renal toxicity in rats

  C CS Li Pre-treated Sim-treated Post-treated
Urea (mg/dl) 26.96 ± 0.30 26.47 ± 0.21 49.10 ± 0.16a 27.22 ± 0.41b 38.48 ± 0.25ab 39.39 ± 0.36ab
Creatinin (mg/dl) 0.73 ± 0.01 0.75 ± 0.01 2.22 ± 0.02a 0.78 ± 0.01b 1.71 ± 0.02ab 1.85 ± 0.02ab
BUN (mg/dl) 8.17 ± 0.09 8.02 ± 0.06 14.88 ± 0.05a 8.25 ± 0.12b 11.66 ± 0.08ab 11.94 ± 0.11ab
T. protein (g/dl) 8.19 ± 0.03 8.09 ± 0.04 4.01 ± 0.08a 7.89 ± 0.10b 5.28 ± 0.02ab 5.89 ± 0.06ab
Uric acid (mg/dl) 4.22 ± 0.03 4.29 ± 0.06 0.80 ± 0.01a 4.31 ± 0.04b 1.61 ± 0.01ab 1.48 ± 0.01ab
  1. Values are expressed as mean ± SE for 8 rats per group
  2. aStatistically difference in comparison with control group (significant at P < 0.05)
  3. bStatistically difference in comparison with Li-treated group (significant at P < 0.05)