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Table 1 Prophylactic and therapeutic effect of chitosan on renal functions against Li2CO3 induced renal toxicity in rats

From: A renoprotective role of chitosan against lithium-induced renal toxicity in rats

 

C

CS

Li

Pre-treated

Sim-treated

Post-treated

Urea (mg/dl)

26.96 ± 0.30

26.47 ± 0.21

49.10 ± 0.16a

27.22 ± 0.41b

38.48 ± 0.25ab

39.39 ± 0.36ab

Creatinin (mg/dl)

0.73 ± 0.01

0.75 ± 0.01

2.22 ± 0.02a

0.78 ± 0.01b

1.71 ± 0.02ab

1.85 ± 0.02ab

BUN (mg/dl)

8.17 ± 0.09

8.02 ± 0.06

14.88 ± 0.05a

8.25 ± 0.12b

11.66 ± 0.08ab

11.94 ± 0.11ab

T. protein (g/dl)

8.19 ± 0.03

8.09 ± 0.04

4.01 ± 0.08a

7.89 ± 0.10b

5.28 ± 0.02ab

5.89 ± 0.06ab

Uric acid (mg/dl)

4.22 ± 0.03

4.29 ± 0.06

0.80 ± 0.01a

4.31 ± 0.04b

1.61 ± 0.01ab

1.48 ± 0.01ab

  1. Values are expressed as mean ± SE for 8 rats per group
  2. aStatistically difference in comparison with control group (significant at P < 0.05)
  3. bStatistically difference in comparison with Li-treated group (significant at P < 0.05)