Changes in tryptophan and phenylalanine in chronic HCV patients treated with direct acting antiviral (sofosbuvir)

Bulletin of the National Research Centre

Table 1 Comparing the studied groups regarding liver function tests

Variable	Untreated HCV cases (n = 40)			Treated HCV cases (n = 40)			Controls (n = 20)			KW test	p
Variable	Mean	± SD	Range	Mean	± SD	Range	Mean	± SD	Range	KW test	p
Age (years)	45.8	11.0	22–65	51.5	12.2	32–77	46.1	12.6	20–67	ANOVA 2.66	0.075 (NS)
ALT (U/l)	24.7	7.54	13–37	28.3	11.56	13–51	18.9	6.02	10–33	9.42	0.009 (S)
AST (U/l)	28.9	8.28	19–44	36.6	11.03	20–60	25.8	6.69	16–38	17.8	< 0.001 (HS)
Albumin (g/dl)	3.95	0.66	2.1–5.1	3.90	0.64	2.2–4.9	4.13	0.50	3.6–5.1	0.62	0.73 (NS)
Total bilirubin (mg/dl)	1.01	0.44	0.6–2.22	0.98	0.42	0.6–2.3	0.75	0.11	0.56–0.92	5.25	0.072 (NS)
Direct bilirubin (mg/dl)	0.28	0.26	0.1–0.97	0.26	0.18	0.11–0.92	0.15	0.04	0.1–0.21	7.22	0.027 (S)

KW Kruskal-Wallis test, NS non significant, S significant, HS highly significant