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Bulletin of the National Research Centre

Table 1 Respiratory effects of cigarette smoking

From: Oxidative stress and inflammation: elucidating mechanisms of smoking-attributable pathology for therapeutic targeting

Disease

Key mechanisms

Epidemiological evidence

COPD

Oxidative stress, inflammation, protease imbalance

Clear dose-dependent association

Lung Cancer

Carcinogens, chronic inflammation, DNA damage

90% of cases attributable to smoking

Impaired Lung Development

In utero smoke exposure, oxidative injury

Lower birth weight, reduced lung function

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