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Table 4 Different attitudes based on the results of the change or not of the depth of probe in cases of application of probiotics

From: Application of probiotics as a constituent element of non-surgical periodontal therapy for cases with chronic periodontitis

Evaluation

Results

Conclusions

Elementi + 

Probiotics are given in the form of tablets 2 times a day and contain L. reuteri (Ausenda et al. 2023)

It is necessary to know which form of administration of probiotics is most effective (Ausenda et al. 2023)

Oral application of probiotics in any type of administration is effective (Mishra et al. 2021)

Antimicrobial effects of probiotics need to be further investigated (Mishra et al. 2021)

Reduction after 6 months of use in gel form of probiotics (Donos et al. 2020)

The long-term effect of probiotics and the modulatory host effect should be seen (Donos et al. 2020)

Probiotics add to the positive effect of periodontitis treatment with non-surgical periodontal therapy (Minić et al. 2022)

The positive effect of probiotics is observed after 1 month of application (Minić et al. 2022)

L.reuteri has a positive effect against P.gingivalis, even if it is taken in the form of tablets (Galofré et al. 2018)

L. reuteri should be applied as a tablet once a day for 30 days. Its effect on peri-implantitis should be checked (Galofré et al. 2018)

The effects of probiotics as an oral cavity rinse are clearly observed after 1 month and after 3 months of application (Ghasemi et al. 2020)

Probiotics are effective even if they are used as rinses of the oral cavity (Ghasemi et al. 2020)

Element + / − 

It only reduces the depth of the pockets by 4-6 mm (Vives-Soler and Chimenos-Küstner 2020)

Accurate application protocols are needed (Vives-Soler and Chimenos-Küstner 2020)

Giving probiotics twice a day for 3 months has the same effects as giving systemic antibiotics for 7 days (Ikram et al. 2019)

L.reuteri is the probiotic as effective as antibiotics for the treatment of chronic periodontitis (Ikram et al. 2019)

The application of the probiotic containing L. reuteri is effective for reducing pockets proven after 21 days and after 3 months of application (Song and Liu 2020)

The healing effect of the probiotic is short term (Song and Liu 2020)

Application of L. reuteri reduces the depth of pockets when applied 2 tablets per day for 21 consecutive days (Theodoro et al. 2019)

Probiotics do not reduce the depth of moderate or severe deep pockets (Theodoro et al. 2019)

Application of probiotics reduces the depth of pockets (20)

The reduction of pocket depth by probiotics is the same as with the application of chlorhexidine in Curasept Periodontal Gel (Butera et al. 2022)

Element − 

The depth of the pockets varies in the same way as in the case of applying only gingival curettage (Patyna et al. 2021)

Further studies are needed to determine the added effects of probiotic treatment (Patyna et al. 2021)

There is no difference in the reduction of pocket depth even after 3 months if we use Bifidobacterium animalis (Özener et al. 2023)

The administration of probiotics has shown limited clinical and microbiological effects in the treatment of patients with periodontitis (Özener et al. 2023)

Probiotics can be used as host modulators, but the results are the same as applying other medicinal healing formulas (Corbella et al. 2021)

So far, there are conflicting data on the effect of probiotics for the treatment of chronic periodontitis (Corbella et al. 2021)

 

L. reuteri with the application in the form of tablets 2 times a day for 28 days did not bring increased clinical efficacy compared to non-periodontal surgical therapy (Pelekos et al. 2019)

There are no statistically significant intergroup differences in the advantages recorded at different time points (Pelekos et al. 2019)