InflANNet: a neural network predictor for Influenza A CTL and HTL epitopes to aid robust vaccine design

Bulletin of the National Research Centre

Table 7 A tabular column representing the various epitope sequences with their binding activity for MHC-I and MHC-II alleles

Sequence Number	Peptide Sequence	Category as predicted by the ML model	Average Binding score with all MHC-I alleles	Average adjusted rank with all MHC-II alleles
1	CVNGSCFTV	Vaccine candidate	0.006149	292.017
2	ETFKVIGGW	Vaccine candidate	0.10571	232.0263
3	GLISLILQI	Vaccine candidate	0.09898	85.10259
4	NSDTVDWSW	Vaccine candidate	0.10318	381.5259
5	VSFDQNLDY	Vaccine candidate	0.137908	242.0352
6	QIAILVTTV	Vaccine candidate	0.066832	128.2119
7	DTVHDRTPY	Vaccine candidate	0.067977	392.1711
8	GRADTKILF	Vaccine candidate	0.011991	267.513
9	LMNELGVPF	Vaccine candidate	0.061249	164.0478
10	ASVLSGGEL	Non-Vaccine candidate	0.003676	315.0611
11	GELDRWEKI	Non-Vaccine candidate	0.063312	403.5344
12	GQLDRWEKI	Non-Vaccine candidate	0.03727	339.5222
13	RWEKIRLRP	Non-Vaccine candidate	0.001314	170.6922
14	KIRLRPGGK	Non-Vaccine candidate	0.036533	275.6174
15	KIRLRPGGK	Non-Vaccine candidate	0.036533	275.6174
16	IRLRPGGKK	Non-Vaccine candidate	0.001474	262.7644
17	RLRPGGKKQ	Non-Vaccine candidate	0.01552	393.1656
18	RPRPGGKKK	Non-Vaccine candidate	0.024531	469.9785

A high binding score corresponds to effective binding with MHC-I alleles and a low adjusted rank corresponds to effective binding with MHC-II alleles. For each epitope, the binding scores and the adjusted ranks were taken as an average of 27 different alleles for MHC-I and MHC-II separately