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Bulletin of the National Research Centre
Fig. 3 | Bulletin of the National Research Centre

Fig. 3

From: Supplementation of rapamycin during in vitro maturation promotes oocyte quality and subsequent embryo development in bovine

Fig. 3

The graphical representation of the mechanisms by which rapamycin improves oocyte quality and subsequent embryo development. The addition of rapamycin during maturation suppresses ROS production, which facilitates the cumulus cells-oocyte gap-junctional communication. Thereby, metabolites transfer from cumulus cell to oocyte easily, which turn on to increase intra-oocyte GSH synthesis. This high content of intra-oocyte GSH maintains intracellular homeostasis and enhances the oocyte maturation process and developmental competence. Thus, in vitro maturation with rapamycin improves the oocyte quality and subsequent embryonic development in the bovine model

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