Table 4 TH epitopes with its binding allele (IC50 < 500 nM)
S.no | HTL epitope | Position | Allele | IC50 | Antigenicity (VaxiJen score) |
|---|---|---|---|---|---|
1 | GLFLIDPSGEIRHSL | Thioredoxin peroxidase (156–170) | HLA-DRB3*01:01 | 27 | 0.5924 |
HLA-DRB1*03:01 | 179 | ||||
HLA-DRB1*07:01 | 192 | ||||
HLA-DRB1*01:01 | 263 | ||||
HLA-DRB1*13:02 | 350 | ||||
HLA-DRB5*01:01 | 403 | ||||
2 | FNPILESNSNGTLNI | Cuticular glycoprotein gp29 (83–97) | HLA-DRB1*13:02 | 38 | 0.6509 |
HLA-DRB1*01:01 | 212 | ||||
HLA-DRB1*07:01 | 235 | ||||
HLA-DRB1*04:01 | 259 | ||||
HLA-DRB1*04:05 | 371 | ||||
HLA-DRB1*04:04 | 471 | ||||
3 | SSFCYIQETVRGSVD | Thioredoxin (8–22) | HLA-DRB5*01:01 | 40 | 0.4336 |
HLA-DRB1*01:01 | 142 | ||||
HLA-DRB1*07:01 | 181 | ||||
HLA-DRB1*11:01 | 406 | ||||
HLA-DRB1*04:01 | 448 |