A combined 2-D and 3-D QSAR modeling, molecular docking study, design, and pharmacokinetic profiling of some arylimidamide-azole hybrids as superior L. donovani inhibitors

Bulletin of the National Research Centre

Table 8 Y-randomization test parameters

Iteration	R	R²	Q²
Random 1	0.498658	0.248660	− 0.17040
Random 2	0.115103	0.013249	− 0.55512
Random 3	0.318787	0.101625	− 0.88510
Random 4	0.572381	0.327620	− 0.17467
Random 5	0.430382	0.185229	− 0.26640
Random 6	0.364943	0.133183	− 0.59773
Random 7	0.235410	0.055418	− 0.45178
Random 8	0.486282	0.236470	− 0.27500
Random 9	0.466289	0.217426	− 0.18640
Random 10	0.513190	0.263364	− 0.27803
Random models parameters
Average R	0.400143
Average R²	0.178224
Average Q²	− 0.38406
cRp^2	0.877748

\({cR}_{p}^{2}\) -Y—randomization coefficient, R—correlation coefficient for Y—randomization, R²—correlation coefficient, Q²—cross-validated R.²