Table 2 Effects of ketamine on RAF of ethanol leaf extract of Ipomoea asarifolia on PTZ-induced seizure in mice
Treatment (mg/kg) | Onset of seizures (min.) | Quantal protection | %Protection against seizures | %Protection against mortality |
|---|---|---|---|---|
D/W (10 ml/kg) | 4.00 ± 0.26 | 0/6 | 0.00 | 66.67 |
RAF (75) | 10.17 ± 1.70* | 1/6 | 16.67 | 83.33 |
KETA (200) | 1.17 ± 0.17* | 0/6 | 0.00 | 83.33 |
KETA (200) + RAF (75) | 2.33 ± 0.67# | 0/6 | 0.00 | 50.00 |
SV (200) | – | 6/6 | 100.00 | 100.00 |
KETA (200) + SV (200) | 17.50 ± 0.50** | 4/6 | 66.67 | 100.00 |
DZP (5) | – | 6/6 | 100.00 | 100.00 |
KETA (200) + DZP (5) | – | 6/6 | 100.00 | 100.00 |